INT287251

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.86
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PKN1) signal transduction (PKN1) histone binding (PKN1)
plasma membrane (PKN1) nucleus (PKN1) intracellular (PKN1)
PKN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 23 98.30 Very High Very High Very High
Anterior cingulate cortex 5 62.28 Quite High
imagery 12 20.56 Low Low
adenocard 250 5.00 Very Low Very Low Very Low
positron emission tomography 25 5.00 Very Low Very Low Very Low
Neurobehavioral 15 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
Limbic system 15 5.00 Very Low Very Low Very Low
Thalamus 15 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 521 99.72 Very High Very High Very High
Cognitive Disorder 102 63.88 Quite High
Persistent Vegetative State 1 26.72 Quite Low
Convulsion 5 11.52 Low Low
Stress 20 5.00 Very Low Very Low Very Low
Depression 15 5.00 Very Low Very Low Very Low
Unconsciousness 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Dyssomnias 5 5.00 Very Low Very Low Very Low
Syndrome 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the current collection of empirical observations, it seems reasonable to conclude that the amplitude reduction of N1 and P300 after SD and the amplitude enhancement of those components after a dose of caffeine are both related to changes in attention and thus to changes in sensory processing, albeit in opposite directions.
Negative_regulation (reduction) of N1 associated with sleep disorders
1) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.32 Pain Relevance 0.03
The importance of N1 as a marker for attentional processing is underscored by the clinical observation that patients with frontal lesions exhibit a reduction in N1 amplitude, and a concomitant disruption of attentional capacities [72].
Negative_regulation (reduction) of N1
2) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.29 Pain Relevance 0
Similarly, N1 amplitude reduction can also be induced by SD.
Negative_regulation (reduction) of N1 associated with sleep disorders
3) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.36 Pain Relevance 0
For example, using an auditory oddball paradigm (in which participants had to respond to infrequently appearing target stimuli), Cote and colleagues [73] observed a marked N1 amplitude reduction in participants who had suffered a night of sleep fragmentation.
Negative_regulation (reduction) of N1
4) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.44 Pain Relevance 0
N1 amplitude reduction after SD is not restricted to auditory responses [74–76], but is also observed for visual- [77] and motor-evoked potentials [76].
Negative_regulation (reduction) of N1 associated with sleep disorders
5) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.46 Pain Relevance 0
The anesthesia procedure by means of step-wise administration of propofol, has displayed a gradual loss of N1.
Negative_regulation (loss) of N1 associated with anesthesia
6) Confidence 0.00 Published 2010 Journal Nonlinear Biomed Phys Section Body Doc Link PMC2880803 Disease Relevance 0 Pain Relevance 0.22

General Comments

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