INT287261

Context Info Confidence 0.42 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.23 Pain Relevance 0.22

transport (Trpm8) transmembrane transport (Trpm8)

Trpm8 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 4 96.12 agonist 20 85.20 antagonist 27 81.44 TRP channel 4 66.16 addiction 5 29.12 withdrawal 32 26.08 imagery 12 5.00 qutenza 7 5.00 Pain 5 5.00 allodynia 4 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 59 98.66 Sprains And Strains 1 54.08 Neuropathic Pain 6 5.00 Pain 5 5.00 Nociception 4 5.00 Injury 2 5.00 Immunization 1 5.00 Ganglion Cysts 1 5.00 Nervous System Injury 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overall, our data suggest a sequential model of TRPM8 gating where chemical modulators can favour (e.g. menthol) or hinder (e.g.

Negative_regulation (model) of TRPM8 Binding (hinder) of

1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18

The results of the in vivo studies with icilin and LPC agree well with our earlier in vitro studies [6] demonstrating that LPLs produced by iPLA2 play an important role in regulating the cold sensitivity of TRPM8. iPLA2 inhibition with BEL reduced the cold hypersensitivity induced by icilin, consistent with our in vitro findings that BEL inhibited TRPM8 responses to icilin.

Negative_regulation (inhibited) of TRPM8 Binding (responses) of associated with hypersensitivity

2) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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