INT287261

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 4 96.12 Very High Very High Very High
agonist 20 85.20 High High
antagonist 27 81.44 Quite High
TRP channel 4 66.16 Quite High
addiction 5 29.12 Quite Low
withdrawal 32 26.08 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
qutenza 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
allodynia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 59 98.66 Very High Very High Very High
Sprains And Strains 1 54.08 Quite High
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, our data suggest a sequential model of TRPM8 gating where chemical modulators can favour (e.g. menthol) or hinder (e.g.
Negative_regulation (model) of TRPM8 Binding (hinder) of
1) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18
The results of the in vivo studies with icilin and LPC agree well with our earlier in vitro studies [6] demonstrating that LPLs produced by iPLA2 play an important role in regulating the cold sensitivity of TRPM8. iPLA2 inhibition with BEL reduced the cold hypersensitivity induced by icilin, consistent with our in vitro findings that BEL inhibited TRPM8 responses to icilin.
Negative_regulation (inhibited) of TRPM8 Binding (responses) of associated with hypersensitivity
2) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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