INT287270

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.78
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
brain 1
podocytes 1
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 37 90.00 High High
imagery 88 87.12 High High
agonist 16 76.16 Quite High
cytokine 6 61.60 Quite High
cerebral cortex 18 58.92 Quite High
Chronic pancreatitis 22 53.48 Quite High
interneuron 3 29.28 Quite Low
chemokine 4 28.40 Quite Low
Hippocampus 33 23.84 Low Low
Thalamus 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 54 93.76 High High
Pancreatic Cancer 44 92.76 High High
Apoptosis 2 91.40 High High
Adenocarcinoma 58 88.80 High High
Cancer 309 86.44 High High
Breast Cancer 28 79.12 Quite High
Metastasis 118 71.68 Quite High
Hyperplasia 2 68.36 Quite High
Pancreatitis 22 53.48 Quite High
Melanoma 4 50.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, respectively). b Protein:protein interaction: The conformational changes that occur upon interaction between ezrin and PKC?
ezrin Binding (interaction) of
1) Confidence 0.36 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.26 Pain Relevance 0.12
Ezrin linking the cell membrane to actin cytoskeleton allows a cell to interact with its microenvironment and provides an "intracellular scaffolding" that facilitates signal transduction through a number of growth factor receptors and adhesion molecules [2,11,33].
Ezrin Binding (interact) of associated with adhesions
2) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.52 Pain Relevance 0.05
Ezrin also binds to filamentous actin through its carboxyl (C)-terminal domains [8].
Ezrin Binding (binds) of
3) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.23 Pain Relevance 0
Another control is provided by an irrelevant Cy3-labeled antibody against a protein that is known not to interact with ezrin.
ezrin Binding (interact) of
4) Confidence 0.35 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.43 Pain Relevance 0.42
In kidney podocytes PC forms a complex with Ezrin and the NHERF2, which promotes RhoA activation and stabilizes the actin cytoskeleton [25], [34].
Ezrin Binding (complex) of in podocytes
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.16 Pain Relevance 0.03
In the present study, we found that brain PC interacts with the Ezrin/NHERF1-2/RhoA-G complex, thereby suggesting that activation of this protein complex is responsible for the reduction in neurite growth and branching observed in PC loss-of-function models.
Ezrin Binding (interacts) of in brain
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.17 Pain Relevance 0.06
Experiments using an antibody recognizing the Ezrin/Radixin/Moesin family of proteins gave similar results (Fig. 2e).
Ezrin Binding (recognizing) of
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0
In addition to AP50, the same yeast two-hybrid screen identified ezrin as a potentially direct binding partner of the ?
ezrin Binding (binding) of
8) Confidence 0.08 Published 2010 Journal Journal of Receptor and Signal Transduction Research Section Body Doc Link PMC3018134 Disease Relevance 0 Pain Relevance 0.07

General Comments

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