INT28728

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Context Info
Confidence 0.46
First Reported 1983
Last Reported 2010
Negated 6
Speculated 5
Reported most in Abstract
Documents 49
Total Number 54
Disease Relevance 13.15
Pain Relevance 21.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
PFC 9
amygdala 5
brain 2
prefrontal 2
midbrain 1
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 734 100.00 Very High Very High Very High
Nucleus accumbens 428 100.00 Very High Very High Very High
amygdala 379 100.00 Very High Very High Very High
Hippocampus 185 100.00 Very High Very High Very High
Ventral tegmentum 123 100.00 Very High Very High Very High
Thalamus 81 100.00 Very High Very High Very High
Locus ceruleus 65 100.00 Very High Very High Very High
noradrenaline 54 100.00 Very High Very High Very High
drug abuse 5 99.98 Very High Very High Very High
gABA 28 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 208 100.00 Very High Very High Very High
Stress 152 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 9 100.00 Very High Very High Very High
Drug Dependence 9 99.98 Very High Very High Very High
Cognitive Disorder 170 99.96 Very High Very High Very High
Depression 76 99.84 Very High Very High Very High
Immunization 12 99.84 Very High Very High Very High
Schizophrenia 39 99.60 Very High Very High Very High
Affective Disorder 8 99.56 Very High Very High Very High
Hypersensitivity 5 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antagonists alone produced stimulation of PFC following i.p. administration in the rat, but did not affect PFC response upon in vitro treatment.
Neg (not) Regulation (affect) of PFC associated with antagonist
1) Confidence 0.46 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7706440 Disease Relevance 0 Pain Relevance 0.59
Treatment with the selective kappa opioid antagonist nor-binaltorphimine blocked the effect of cFP-AAF-pAB on milk-induced opioid activity, but treatment with the mu antagonist CTOP or the delta antagonist naltrindole did not.
Regulation (effect) of cFP associated with antagonist and opioid
2) Confidence 0.44 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7911578 Disease Relevance 0 Pain Relevance 0.64
The role of brain delta- and kappa-opioid receptors in the regulation of PFC response, Arthus hypersensitivity reactions and delayed hypersensitivity reactions was studied following intracerebroventricular (i.c.v.) administration of opioid receptor agonists and antagonists.
Regulation (regulation) of PFC in brain associated with antagonist, hypersensitivity, agonist, kappa opioid receptor, opioid receptor and intracerebroventricular
3) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834369 Disease Relevance 0.20 Pain Relevance 0.60
With regards to the initial research questions whether cognitive flexibility is dependent on mPFC 5-HT, the present data suggest that in both the spatial and the odour tasks, the lesioned animals are fully capable of acquiring a reversal, show appropriate extinction learning in the absence of a reinforcer and exert normal inhibitory control.
Spec (whether) Regulation (dependent) of mPFC associated with cognitive disorder
4) Confidence 0.42 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.35 Pain Relevance 0.06
After implanting stimulating electrodes in the prefrontal cortex (PFC) of adult male rats, the response to PFC stimulation was studied in widely scattered neurons of the midbrain.
Regulation (response) of PFC in prefrontal associated with midbrain
5) Confidence 0.39 Published 1985 Journal Brain Res. Section Abstract Doc Link 4027627 Disease Relevance 0.07 Pain Relevance 0.27
Acute administration of fluoxetine (10 mg/kg, iv) also did not change the firing rate of PFC neurons.
Neg (not) Regulation (change) of PFC in PFC associated with fluoxetine
6) Confidence 0.39 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951202 Disease Relevance 0.16 Pain Relevance 0.56
Acute or 5-day administration of olanzapine (1-10 mg/kg, iv or 20 mg/kg, sc) did not change the firing rate of PFC neurons.
Neg (not) Regulation (change) of PFC in PFC
7) Confidence 0.39 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951202 Disease Relevance 0.18 Pain Relevance 0.45
CONCLUSIONS: Reversible reduction of LC-NE activity by clonidine impaired measures of visuospatial attention sensitive to PFC lesions but were insufficient to affect PFC- or hippocampal-dependent measures of spatial working memory.
Regulation (affect) of PFC in PFC
8) Confidence 0.39 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15830223 Disease Relevance 0 Pain Relevance 0
In the present study, we examined effects of local application of PCP to the ventral hippocampus (vHIP) on firing activity of PFC neurons in freely moving rats.
Spec (examined) Regulation (effects) of PFC in ventral associated with hippocampus
9) Confidence 0.38 Published 2005 Journal Cereb. Cortex Section Abstract Doc Link 15342431 Disease Relevance 0.16 Pain Relevance 0.26
These deficits may reflect altered neuromodulation of the orbitofrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine (DA) projections.
Regulation (neuromodulation) of PFC in PFC associated with dopamine
10) Confidence 0.38 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10088133 Disease Relevance 0.16 Pain Relevance 0.29
Together, these three currents controlled the firing threshold of the PFC neurons.
Regulation (controlled) of PFC in neurons
11) Confidence 0.37 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8774458 Disease Relevance 0 Pain Relevance 0.27
Miller (2000) has described the PFC as a control centre over overt behaviour that regulates ‘active maintenance of patterns of activity that represent goals and the means to achieve them.’
Regulation (control) of PFC
12) Confidence 0.37 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.07 Pain Relevance 0
Since beta-FNA alone had no effect on PFC response (unlike ICI 174,864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of delta and kappa opioid receptors.
Regulation (response) of PFC in brain associated with kappa opioid receptor and mu opioid receptor
13) Confidence 0.26 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8964897 Disease Relevance 0 Pain Relevance 0.61
It was also observed that the microiontophoretic administration of either ME or NE frequently (100% and 52% respectively) mimicked the response to PFC stimulation, thereby suggesting that these neurotransmitters may be involved in mediating the PFC influence upon neurons in the midbrain.
Regulation (influence) of PFC in midbrain associated with neurotransmitter and midbrain
14) Confidence 0.24 Published 1985 Journal Brain Res. Section Abstract Doc Link 4027627 Disease Relevance 0.07 Pain Relevance 0.30
Thus, the interplay among these structures critical for goal-directed behavior appears to be complex, and their impact on an output that may serve channeling their information into behavior can vary depending on the activity levels of the PFC.
Regulation (depending) of PFC
15) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.29
Perseveration is a common observation in frontal lobe deficits and certain disorders that affect the PFC, such as schizophrenia [40].
Regulation (affect) of PFC in lobe associated with schizophrenia
16) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0.29 Pain Relevance 0.20
However, this particular distinction between PFC functions might be rather specific to visual- and odour-based learning in rats (Chudasama and Robbins 2003; Schoenbaum et al. 2002) and primates (Clarke et al. 2005, 2007), as several groups have reported an involvement of the mPFC in reversal learning using spatial discriminations (Kolb et al. 1974; Li and Shao 1998; Salazar et al. 2004; De Bruin et al. 2000).
Regulation (involvement) of mPFC
17) Confidence 0.22 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
These data demonstrate that the basal output of dopamine terminals in the medial striatum is under a tonic excitatory control of the PFC.
Regulation (control) of PFC in medial associated with dopamine
18) Confidence 0.22 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8592128 Disease Relevance 0 Pain Relevance 0.83
In addition to affecting GluA1 subunits, we observed that acute stress modulates the phosphorylation state of the GluA2 subunit in amygdala, mPFC and VH.
Regulation (modulates) of mPFC in amygdala associated with stress, hippocampus and amygdala
19) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.58 Pain Relevance 0.62
These data suggest that D1 receptors in the PFC are involved in working memory processes other than just the short-term active retention of information and also provide direct evidence for DA modulation of limbic-PFC circuits during behavior.
Regulation (modulation) of limbic-PFC in PFC associated with dopamine
20) Confidence 0.22 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9454866 Disease Relevance 0 Pain Relevance 0.23

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