INT28729

Context Info Confidence 0.43 First Reported 1988 Last Reported 2005 Negated 1 Speculated 1 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0.33 Pain Relevance 2.79

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency brain 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 13 100.00 cocaine 7 100.00 narcan 5 100.00 guanethidine 2 100.00 Opioid 6 99.98 antagonist 4 99.96 Morphine 7 99.20 tolerance 7 98.84 Eae 1 97.04 tetrodotoxin 1 96.88

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 2 84.64 Glioma 1 84.52 Neuroblastoma 1 84.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have also demonstrated that opioid receptor blockade with naloxone antagonizes completely the locomotor-activating effect of cocaine and attenuates the strength of the place preference conditioning produced by cocaine.

Negative_regulation (attenuates) of Negative_regulation (blockade) of opioid receptor associated with narcan, opioid receptor and cocaine

1) Confidence 0.43 Published 1989 Journal Brain Res. Section Abstract Doc Link 2790454 Disease Relevance 0.16 Pain Relevance 0.81

Previously, we have used the biochemical receptor binding method to investigate whether down-regulation of the opioid receptor is a mechanism for morphine tolerance, and we were led to a negative conclusion.

Spec (whether) Negative_regulation (down) of Spec (whether) Negative_regulation (regulation) of opioid receptor associated with tolerance, opioid receptor and morphine

2) Confidence 0.36 Published 2000 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 10786934 Disease Relevance 0 Pain Relevance 0.48

Opioid inhibition of adenylate cyclase and opioid receptor down-regulation also have been observed in the brain.

Negative_regulation (inhibition) of Negative_regulation (regulation) of opioid receptor in brain associated with opioid receptor and opioid

3) Confidence 0.08 Published 1988 Journal Synapse Section Abstract Doc Link 2847342 Disease Relevance 0.17 Pain Relevance 1.05

These responses were not influenced by the ganglionic blocking drug hexamethonium (50 microM), or a combination of the adrenergic neurone blocking drug guanethidine (3 microM), the opioid receptor antagonist naloxone (0.5 microM) and the nitric oxide synthase inhibitor N(G)-nitro-L-arginine (L-NOARG; 100 microM), but were strongly reduced or abolished by the P2 purinoceptor antagonist PPADS (30 microM) or by tachyphylaxis evoked by 10 microM alpha,beta-meATP.

Neg (not) Negative_regulation (influenced) of Negative_regulation (combination) of opioid receptor associated with guanethidine, antagonist, narcan and opioid receptor

4) Confidence 0.01 Published 2005 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16364052 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.