INT287307

Context Info Confidence 0.48 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 11.24 Pain Relevance 2.51

small molecule metabolic process (ENO1) lyase activity (ENO1) carbohydrate metabolic process (ENO1) DNA binding (ENO1) cytoplasm (ENO1) cytosol (ENO1)

Anatomy Link Frequency blood 2 artery 1 nucleus 1 ENO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Piles 345 100.00 cva 317 100.00 Acute pain 3 89.92 Perioperative pain 9 88.56 Pain 53 80.00 Lasting pain 27 54.24 Prostatitis 3 49.20 Bile 3 47.28 Inflammation 3 37.44 analgesia 4 36.68

Disease Link Frequency Relevance Heat Anorectal Disorders 345 100.00 Cv General 3 Under Development 216 100.00 Post-partum Hemorrhage 72 100.00 Shock 28 99.80 Pressure Volume 2 Under Development 230 98.64 Placenta Accreta 6 98.48 Lacerations 14 97.64 Hernia 24 97.24 Syndrome 21 97.16 Failure To Thrive 4 96.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The only study published to date which specifically examines an association between PPH and breastfeeding is a small case series describing insufficient milk syndrome and failure to thrive in infants associated with maternal PPH [6].

PPH Binding (association) of associated with failure to thrive, syndrome and cva

1) Confidence 0.48 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 1.30 Pain Relevance 0.26

Firstly, it was not designed to establish causal associations between the PPH and breastfeeding outcomes.

PPH Binding (associations) of associated with cva

2) Confidence 0.42 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 0.34 Pain Relevance 0.09

Reasons for admission to either HDU or ICU were not well reported, but for those 16 women where a reason was recorded all related to complications associated with the PPH.

PPH Binding (associated) of associated with cva

3) Confidence 0.42 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 0.37 Pain Relevance 0.10

Instead, Aigner et al. demonstrated with anatomical dissections that neither PPH nor Doppler ligation completely interrupt the superior rectal artery branches, and of course there is still the vascular supply from below [41].

PPH Neg (neither) Binding (ligation) of in artery associated with piles

4) Confidence 0.41 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.95 Pain Relevance 0.82

New trends for PPH

PPH Binding (trends) of associated with piles

5) Confidence 0.36 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.59 Pain Relevance 0.35

For example, in one woman's words: "...now it's bothering me that the doctors in hospital would just not listen to me about getting a blood transfusion earlier (I had a PPH previously with my first child) and my recovery and difficulties with breast feeding would have been so much better!"

PPH Binding (had) of in blood associated with cva

6) Confidence 0.32 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 0.69 Pain Relevance 0.13

To be eligible for the study, women presented with PPH and shock, defined by an initial blood loss of ?

PPH Binding (presented) of in blood associated with pressure volume 2 under development, shock and cva

7) Confidence 0.32 Published 2010 Journal Reprod Health Section Body Doc Link PMC2942803 Disease Relevance 1.53 Pain Relevance 0.31

Tenesmus affected 50% of the patients who underwent PPH for fourth-degree hemorrhoids one year after surgery in a prospective randomized trial that compared stapled hemorrhoidopexy with manual hemorrhoidectomy [19].

PPH Binding (underwent) of associated with piles

8) Confidence 0.32 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.35 Pain Relevance 0.36

PPH, a life-threatening condition globally, is associated with 25% of maternal deaths [1].

PPH Binding (associated) of associated with cva

9) Confidence 0.27 Published 2010 Journal Reprod Health Section Body Doc Link PMC2942803 Disease Relevance 0.85 Pain Relevance 0.10

This activated form of Notch1 then translocates to the nucleus and binds with the DNA-binding protein complex CSL (C promoter-binding factor 1, suppressor of hairless and Lag-1), resulting in transactivation of various target genes like hairy enhancer of split-1 (HES-1).

promoter-binding factor 1 Binding (binding) of in nucleus

10) Confidence 0.03 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.27 Pain Relevance 0

General Comments

This test has worked.