INT287308

Context Info Confidence 0.59 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 4.07 Pain Relevance 1.24

small molecule metabolic process (ENO1) lyase activity (ENO1) carbohydrate metabolic process (ENO1) DNA binding (ENO1) cytoplasm (ENO1) cytosol (ENO1)

Anatomy Link Frequency blood 3 placenta 1 ENO1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 198 100.00 Piles 115 100.00 analgesia 10 81.72 epidural 8 81.32 Pain 23 37.96 abdominal pain 17 36.72 Bile 1 26.76 backache 2 12.44 Lasting pain 9 5.00 depression 9 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 144 100.00 Pressure Volume 2 Under Development 125 100.00 Anorectal Disorders 115 100.00 Post-partum Hemorrhage 38 100.00 Shock 14 100.00 Recurrence 7 98.84 Infection 34 97.92 Reprotox - General 1 10 91.12 Hernia 8 76.72 Death 7 76.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both of these factors would tend to reduce PPH and thus the observed excess of PPH in the caesarean group is strengthened.

Negative_regulation (reduce) of PPH associated with cva

1) Confidence 0.59 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC3014869 Disease Relevance 0.78 Pain Relevance 0.30

The decreased use of PPH among members of SICCR, from 26% to 20% in the last three years [106, 113], might well reflect this trend towards a restriction of the indications.

Negative_regulation (decreased) of PPH associated with piles

2) Confidence 0.42 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.60 Pain Relevance 0.43

The study population included women with a significant PPH defined as: an estimated blood loss of 1500 mL or more in the 24 hours following childbirth, and/or a peripartum fall in haemoglobin (Hb) concentration to 7g/dL or less, and/or a peripartum fall in haemoglobin concentration of ?

Negative_regulation (loss) of PPH in blood associated with pressure volume 2 under development and cva

3) Confidence 0.38 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 0.54 Pain Relevance 0.13

Once recruited, participants' medical records were reviewed and data were abstracted on obstetric history, pregnancy factors, labour and delivery in the index pregnancy, estimated blood loss in 24 hours postpartum and PPH management.

Negative_regulation (loss) of PPH in blood associated with pressure volume 2 under development and cva

4) Confidence 0.38 Published 2010 Journal Int Breastfeed J Section Body Doc Link PMC2889881 Disease Relevance 0.39 Pain Relevance 0.08

Clinician/data collectors were trained in the standard management of PPH and shock, collection and measurement of blood loss and completion of data collection forms.

Negative_regulation (loss) of PPH in blood associated with pressure volume 2 under development, shock and cva

5) Confidence 0.37 Published 2010 Journal Reprod Health Section Body Doc Link PMC2942803 Disease Relevance 0.47 Pain Relevance 0.05

Active management included the following aimed at preventing PPH: routine intramuscular (i.m.) injection of a preventive single dose of oxytocin with delivery of the baby, controlled cord traction and uterine massage after delivery of the placenta.

Negative_regulation (preventing) of PPH in placenta associated with cva

6) Confidence 0.37 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC3014869 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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