INT28731

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Context Info
Confidence 0.14
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.97
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
neutrophil 7
lung 2
HPOA 2
plasma 1
macrophage 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 182 99.84 Very High Very High Very High
Inflammation 812 99.48 Very High Very High Very High
narcan 18 99.32 Very High Very High Very High
gABA 4 95.00 High High
agonist 10 94.36 High High
antagonist 99 94.28 High High
Inflammatory stimuli 2 84.20 Quite High
adenocard 4 83.20 Quite High
dexamethasone 7 76.12 Quite High
Neurotransmitter 2 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 843 99.48 Very High Very High Very High
Nicotine Addiction 296 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 98.54 Very High Very High Very High
Emphysema 178 98.32 Very High Very High Very High
Injury 61 97.08 Very High Very High Very High
Pneumonia 75 93.48 High High
Asthma 124 91.16 High High
Pulmonary Disease 1156 90.72 High High
Targeted Disruption 18 85.52 High High
Apoptosis 68 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, IPF patients have higher numbers of neutrophils and higher concentrations of granule enzymes, such as neutrophil elastase, myeloperoxydase, collagenase and lactoferrin in BALF, plasma and lung tissue [30,31].
Negative_regulation (numbers) of neutrophil elastase in plasma
1) Confidence 0.14 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.21 Pain Relevance 0.44
Protein inhibitors of neutrophil elastase administered via nebulisation are also being pursued and supportive data has been obtained for inhaled recombinant ?
Negative_regulation (inhibitors) of neutrophil elastase in neutrophil
2) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.31 Pain Relevance 0.09
These studies suggest inhibition of neutrophil elastase can be anti-inflammatory in addition to preventing emphysema development.
Negative_regulation (inhibition) of neutrophil elastase in neutrophil associated with emphysema and inflammation
3) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.93 Pain Relevance 0.14
These were paralleled with by a reduction in CXCL8 and neutrophil elastase.
Negative_regulation (reduction) of neutrophil elastase in neutrophil
4) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.54 Pain Relevance 0.14
The search for potent, safe oral inhibitors of neutrophil elastase has been going on for over 20 years and many of the compounds that progressed into clinical development failed because of poor pharmacokinetics and a low therapeutic index.
Negative_regulation (inhibitors) of neutrophil elastase in neutrophil
5) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.78 Pain Relevance 0.10
1-PI mutant proteins in the lung, which not only are ineffective inhibitors of NE, but also have chemotactic activity for PMN (Mahadeva et al 2005; Lomas 2006).



Negative_regulation (inhibitors) of NE in lung
6) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.52 Pain Relevance 0.09
1-PI and SLPI have reduced effectiveness against elastin-bound NE compared to soluble NE (Bruch and Bieth 1986; Morrison et al 1990, 1999).
Negative_regulation (effectiveness) of NE
7) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.30 Pain Relevance 0.08
Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds.
Negative_regulation (Inhibition) of neutrophil elastase in neutrophil associated with injury
8) Confidence 0.07 Published 2001 Journal Blood Section Title Doc Link 11133774 Disease Relevance 0.69 Pain Relevance 0
Similarly, a small molecule neutrophil elastase inhibitor, ZD0892, reduced cigarette smoke induced emphysema and pulmonary cells recruitment in a guinea pig model (Wright et al 2002).
Negative_regulation (inhibitor) of neutrophil elastase in neutrophil associated with emphysema
9) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.02 Pain Relevance 0.14
Indeed, IPF patients have higher numbers of neutrophils and higher concentrations of granule enzymes, such as neutrophil elastase, myeloperoxydase, collagenase and lactoferrin in BALF, plasma and lung tissue [30,31].
Negative_regulation (numbers) of neutrophil elastase in lung
10) Confidence 0.05 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.21 Pain Relevance 0.44
Each of these elastases inactivated the endogenous inhibitor of the other, with macrophage elastase degrading alpha1-antitrypsin and neutrophil elastase degrading tissue inhibitor of metalloproteinase-1 [48].
Negative_regulation (inhibitor) of neutrophil elastase in macrophage associated with metalloproteinase
11) Confidence 0.04 Published 2004 Journal Respir Res Section Body Doc Link PMC533858 Disease Relevance 0.69 Pain Relevance 0.05
They include aids to smoking cessation (Richmond and Zwar 2003), antiproteases, including inhibitors of neutrophil elastase (Ohbayashi 2002), matrix metalloprotease inhibitors (Owen 2005; Gueders et al 2006), cathepsin inhibitors (de Garavilla et al 2005), selectin antagonists (Romano 2005), inhibitors of TNF-?
Negative_regulation (inhibitors) of neutrophil elastase in neutrophil associated with nicotine addiction, antagonist and acquired immune deficiency syndrome or hiv infection
12) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.76 Pain Relevance 0.29
CONCLUSIONS: Reversible reduction of LC-NE activity by clonidine impaired measures of visuospatial attention sensitive to PFC lesions but were insufficient to affect PFC- or hippocampal-dependent measures of spatial working memory.
Negative_regulation (reduction) of LC-NE in PFC
13) Confidence 0.01 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15830223 Disease Relevance 0 Pain Relevance 0
Since depletion of HPOA-EPIN by LY 134046 did not compromise the LH response to naloxone, this effect of FLA-63 is due to depletion of HPOA-NE levels. 3) While saline had no effect on the increased pulsatile LH release caused by naloxone, administration of baclofen (GABA-B receptor agonist, 6 mg/kg IV) suppressed the pulsatile LH secretory response to naloxone infusion.
Negative_regulation (depletion) of HPOA-NE in HPOA associated with gaba, agonist and narcan
14) Confidence 0.00 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2790494 Disease Relevance 0 Pain Relevance 0.47
Although basal LH pulse frequency was reduced, this treatment had no effect on the stimulatory action of naloxone on pulsatile LH release. 2) FLA-63 (DBH inhibitor, 25 mg/kg IP) given at -3 hr produced a 72% decline in HPOA-NE levels, a 44% decrease in HPOA-EPIN values, and blocked the stimulatory action of naloxone on LH pulse frequency.
Negative_regulation (decline) of HPOA-NE in HPOA associated with narcan
15) Confidence 0.00 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2790494 Disease Relevance 0 Pain Relevance 0.54

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