INT28733

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Context Info
Confidence 0.12
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.11
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDAR) cell differentiation (EDAR) signal transduction (EDAR)
plasma membrane (EDAR)
EDAR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.12 Very High Very High Very High
lidocaine 5 96.80 Very High Very High Very High
Clonidine 1 87.92 High High
addiction 1 80.56 Quite High
Neuropeptide 100 78.64 Quite High
sodium channel 1 75.92 Quite High
tolerance 8 55.40 Quite High
Opioid 28 5.00 Very Low Very Low Very Low
Enkephalin 17 5.00 Very Low Very Low Very Low
substance P 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 144 100.00 Very High Very High Very High
Acidosis 2 96.94 Very High Very High Very High
Diabetes Mellitus 58 91.60 High High
Obesity 4 75.00 Quite High
Asthma 3 75.00 Quite High
Alkalosis 1 72.32 Quite High
Dyspnea 1 69.68 Quite High
Urological Neuroanatomy 12 20.76 Low Low
Cardiovascular Disease 9 7.68 Low Low
Coronary Artery Disease 19 5.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data was grouped into eight groups: ed12 male controls (ed12MC, n = 5), ed12 female controls (ed12FC, n = 5), ed12 male EE2 (ed12ME, n = 5), ed12 female EE2 (ed12FE, n = 4), ed17 male controls (ed17MC, n = 4)), ed17 female controls (ed17FC, n = 4), ed17 male EE2 (ed17ME, n = 4), and ed17 female EE2 (ed17FE, n = 5) (Table 4).
Regulation (controls) of ed17
1) Confidence 0.12 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0
Removal of sample outliers left 39 MS-data files, of which six were technical replicates (ed12 female control; Q52a-Q52f) to each other, corresponding to 34 unique samples.


Regulation (control) of ed12
2) Confidence 0.12 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0.03
The samples were ed12 male controls (n = 5), ed12 female controls (n = 4), ed12 male EE2 exposed (n = 4), ed12 female EE2 exposed (n = 4), ed17 male controls (n = 4), ed17 female controls (n = 4), ed17 male EE2 exposed (n = 4) and ed17 female EE2 exposed (n = 5).
Regulation (controls) of ed17
3) Confidence 0.12 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0.10
The data was grouped into eight groups: ed12 male controls (ed12MC, n = 5), ed12 female controls (ed12FC, n = 5), ed12 male EE2 (ed12ME, n = 5), ed12 female EE2 (ed12FE, n = 4), ed17 male controls (ed17MC, n = 4)), ed17 female controls (ed17FC, n = 4), ed17 male EE2 (ed17ME, n = 4), and ed17 female EE2 (ed17FE, n = 5) (Table 4).
Regulation (controls) of ed17MC
4) Confidence 0.12 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0
The up-regulation of ET-1 in ED with several etiological causes (including psychogenic causes) suggests that levels are at least partly a response to ED.
Regulation (regulation) of ED associated with reprotox - general 2
5) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.49 Pain Relevance 0
Acidosis produced by hydrochloric acid infusion decreased the arterial pH from 7.40 +/- 0.05 (SD) to 7.18 +/- 0.03 (n = 8, p less than 0.01), but no significant change in ED90 was observed (14 +/- 4 to 16 +/- 6 J).
Neg (no) Regulation (change) of ED90 associated with acidosis
6) Confidence 0.01 Published 1989 Journal Circulation Section Abstract Doc Link 2791234 Disease Relevance 0.32 Pain Relevance 0.48
Sensitivity to terbutaline, a selective beta 2-adrenoceptor agonist, increased 25-fold (P = 0.01), whereas the ED50 values for dobutamine, a selective beta 1-adrenoceptor agonist, did not change significantly.
Regulation (values) of ED50 associated with agonist
7) Confidence 0.00 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8403793 Disease Relevance 0.29 Pain Relevance 0.28

General Comments

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