INT28734

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 5.76
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) molecular_function (Reln)
Anatomy Link Frequency
visceral 2
DRG 2
other parts 1
brainstem 1
spinal cord neurons 1
Reln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 9 99.80 Very High Very High Very High
Spinal cord 6 99.72 Very High Very High Very High
dorsal root ganglion 30 99.40 Very High Very High Very High
medulla 50 98.28 Very High Very High Very High
Central grey 360 97.96 Very High Very High Very High
Morphine 80 96.52 Very High Very High Very High
Pain 3 95.76 Very High Very High Very High
amygdala 50 95.68 Very High Very High Very High
Anterior cingulate 30 95.68 Very High Very High Very High
depression 3 94.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 30 99.40 Very High Very High Very High
Urological Neuroanatomy 373 99.16 Very High Very High Very High
Autism 3 96.52 Very High Very High Very High
Schizophrenia 3 96.20 Very High Very High Very High
Pain 3 95.76 Very High Very High Very High
Manic Depressive Disorder 3 95.60 Very High Very High Very High
Depression 3 94.48 High High
Adhesions 3 55.48 Quite High
Body Weight 10 22.96 Low Low
Cognitive Disorder 10 19.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats.
Gene_expression (expression) of Reelin in frontal cortex associated with urological neuroanatomy
1) Confidence 0.74 Published 2009 Journal Schizophr. Res. Section Title Doc Link 19359144 Disease Relevance 0.47 Pain Relevance 0.20
Again, several of the protein products for Reelin, Vldlr, Dab-1, Gsk3 beta, Gad65, and Gad67 were also significantly altered by multiple drugs.
Gene_expression (products) of Reelin
2) Confidence 0.64 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.34 Pain Relevance 0.22
Disruption of the Reelin and GABAergic signaling systems have been observed in psychiatric disorders including autism, schizophrenia, bipolar disorder, and major depression.
Gene_expression (Disruption) of Reelin associated with manic depressive disorder, autism, depression, gabaergic and schizophrenia
3) Confidence 0.64 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.46 Pain Relevance 0.17
RL-14.5 and RL-29 are expressed soon after the differentiation of DRG neurons and appear to be released from cultured DRG neurons.
Gene_expression (expressed) of RL-29 in DRG associated with dorsal root ganglion
4) Confidence 0.12 Published 1989 Journal Ciba Found. Symp. Section Abstract Doc Link 2791751 Disease Relevance 0.89 Pain Relevance 0.56
DRG and spinal cord neurons also express two soluble beta-galactoside-binding proteins of relative molecular masses 14,500 and 29,000, termed RL-14.5 and RL-29, which represent potential ligands for lactoseries oligosaccharides.
Gene_expression (express) of RL-29 in spinal cord neurons associated with dorsal root ganglion and spinal cord
5) Confidence 0.09 Published 1989 Journal Ciba Found. Symp. Section Abstract Doc Link 2791751 Disease Relevance 0.99 Pain Relevance 0.61
findings, the rlPAG is also in a position to integrate visceral and gustatory
Gene_expression (is) of rlPAG in visceral
6) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0.04
The present findings also revealed that the rlPAG is
Gene_expression (is) of rlPAG
7) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.15 Pain Relevance 0.17
The rlPAG is also significantly targeted by hypothalamic districts that
Gene_expression (targeted) of rlPAG
8) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0
roaches, we were able to show that lesions of the rlPAG, but not other parts of
Gene_expression (lesions) of rlPAG in other parts
9) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.35 Pain Relevance 0.83
that the rlPAG combines a unique set of inputs rendering this region
Gene_expression (combines) of rlPAG
10) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.21 Pain Relevance 0.16
The rlPAG is also significantly targeted by hypothalamic districts that
Gene_expression (The) of rlPAG
11) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0
DRG and spinal cord neurons also express two soluble beta-galactoside-binding proteins of relative molecular masses 14,500 and 29,000, termed RL-14.5 and RL-29, which represent potential ligands for lactoseries oligosaccharides.
Gene_expression (express) of RL-29 in DRG associated with dorsal root ganglion and spinal cord
12) Confidence 0.03 Published 1989 Journal Ciba Found. Symp. Section Abstract Doc Link 2791751 Disease Relevance 0.99 Pain Relevance 0.61
In

contrast, the rlPAG appears to receive inputs from considerably fewer brainstem

Gene_expression (appears) of rlPAG in brainstem associated with medulla
13) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.15 Pain Relevance 0.16
As for the rlPAG,
Gene_expression (for) of rlPAG
14) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.54 Pain Relevance 0.38
have also found that the rlPAG receives projections from visceral, gustatory,
Gene_expression (receives) of rlPAG in visceral
15) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.08 Pain Relevance 0.14
chemical stimulation with kainic acid (KA) in the region of the rlPAG produced
Gene_expression (produced) of rlPAG
16) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.16 Pain Relevance 0.08

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