INT287374

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.70 Pain Relevance 0

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70) nucleus (SNRNP70)

SNRNP70 (Homo sapiens) rs (Mus musculus)

Pain Link Frequency Relevance Heat Angina 2 5.00

Disease Link Frequency Relevance Heat Exfoliation Syndrome 122 99.76 Glaucoma 84 99.60 Obesity 4 76.28 Ocular Hypertension 12 5.00 Disease 8 5.00 Cataract 4 5.00 Syndrome 4 5.00 Fibrosis 2 5.00 Hypertension 2 5.00 Uveitis 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Besides rs1048661, SNPs rs3825942 and rs2165241 were also significantly associated with XFS/XFG individually.

SNP Binding (associated) of rs1048661 associated with exfoliation syndrome and glaucoma

1) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.79 Pain Relevance 0

The rs1048661 is the predominant SNP associated with XFS/XFG in our study cohort.

SNP Binding (associated) of rs1048661 associated with exfoliation syndrome and glaucoma

2) Confidence 0.00 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.91 Pain Relevance 0

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