INT287385

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 4
Nstr2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Optic Nerve Injuries 378 99.92 Very High Very High Very High
Death 24 25.00 Low Low
Ganglion Cysts 12 25.00 Low Low
Injury 48 5.00 Very Low Very Low Very Low
Ocular Hypertension 18 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Eye Disease 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that reductions in the pSTR and nSTR continue a long time after ONT, and thus appear to be permanent (Figures 9A,B) for both albino and pigmented rats.
Negative_regulation (reductions) of nSTR associated with optic nerve injuries
1) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.44 Pain Relevance 0
At this point after ONT, the reduced pSTR and nSTR responses from operated eyes amounted to approximately 55% of those values recorded for the unoperated eyes (t-test, p<0.001), while no other apparent differences in ERG scotopic and mixed responses were observed between operated and unoperated eyes.
Negative_regulation (reduced) of nSTR in eyes associated with optic nerve injuries
2) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.48 Pain Relevance 0
Reduced pSTR and nSTR responses from operated eyes amounted to 65% of those of the unoperated eyes (t-test, p<0.001), and these are clearly observed at two weeks after ONT (Figure 3A).
Negative_regulation (Reduced) of nSTR in eyes associated with optic nerve injuries
3) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.67 Pain Relevance 0
Reduced pSTR and nSTR responses from operated eyes amounted to 55% of those of the unoperated eyes (t-test, p<0.001).
Negative_regulation (Reduced) of nSTR in eyes
4) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.52 Pain Relevance 0
ERG traces from albino animals in group I (n=6) examined one week after ONT showed reductions in the pSTR and nSTR responses of approximately 40% when compared to the unoperated contralateral eye (t-test, p<0.001).
Negative_regulation (reductions) of nSTR in eye associated with optic nerve injuries
5) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779069 Disease Relevance 0.51 Pain Relevance 0
Twelve weeks after ONT, the pSTR and nSTR remained significantly reduced to approximately 40% and 70%, respectively; whereas the a- and b-waves reached values of approximately 80%.


Negative_regulation (reduced) of nSTR associated with optic nerve injuries
6) Confidence 0.04 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2779069 Disease Relevance 0.71 Pain Relevance 0

General Comments

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