INT28739

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Context Info
Confidence 0.37
First Reported 1989
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 22.43
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 6
muscle 4
adipose tissue 3
blood 1
liver 1
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 100.00 Very High Very High Very High
Hippocampus 30 99.92 Very High Very High Very High
Neuropeptide 11 98.44 Very High Very High Very High
tolerance 164 98.30 Very High Very High Very High
gABA 1 97.98 Very High Very High Very High
Catecholamine 1 97.08 Very High Very High Very High
Pain 15 94.24 High High
alcohol 8 91.32 High High
cerebral cortex 10 89.68 High High
Inflammation 182 88.52 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 363 100.00 Very High Very High Very High
Hyperglycemia 61 99.88 Very High Very High Very High
Obesity 493 99.80 Very High Very High Very High
Metabolic Disorder 99 99.76 Very High Very High Very High
Fatty Liver 87 99.76 Very High Very High Very High
Metabolic Syndrome 123 99.52 Very High Very High Very High
Diabetes Mellitus 714 98.76 Very High Very High Very High
Shock 107 98.72 Very High Very High Very High
Sprains And Strains 65 96.40 Very High Very High Very High
Cardiovascular Disease 90 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The emotional-pain stress (EPS) in C57BL mice with Lewis carcinoma was studied for its influence on serotoninergic, noradrenergic, dopaminergic, glutamatergic, aspartatergic, glycinergic, taurinergic, GABA-ergic and cholinergic mediator mechanisms of the hypothalamus, the level of corticotropin, free and bound 11-corticosteroids, insulin, thyroxin and testosterone in blood plasma as well as on the content of catecholamines, their precursors and catabolites in urine.
insulin Binding (bound) of in plasma associated with stress, pain, corticosteroid, gaba, catecholamine and carcinoma
1) Confidence 0.37 Published 1989 Journal Eksp. Onkol. Section Abstract Doc Link 2791954 Disease Relevance 1.00 Pain Relevance 0.32
When insulin binds to its receptor induces a conformational change in the receptor and leads to activation of its tyrosine-kinase domain.
insulin Binding (binds) of
2) Confidence 0.30 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.32 Pain Relevance 0.03
Plasma adiponectin levels decrease during obesity, and are negatively associated with plasma insulin, positively associated with plasma triglycerides, and correlate with increases in HOMA-IR [6].
insulin Binding (associated) of in plasma associated with metabolic syndrome
3) Confidence 0.24 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.11 Pain Relevance 0.09
It is characterized by a combination of factors that affect the organism's ability to respond to insulin.
insulin Binding (respond) of
4) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 1.90 Pain Relevance 0
Mice used for other experiments (acute insulin and adipose tissue FACS studies, n?
insulin Binding (experiments) of in adipose tissue associated with obesity
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.81 Pain Relevance 0.06
these animals which is associated with significantly reduced islet insulin
insulin Binding (associated) of
6) Confidence 0.16 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2443691 Disease Relevance 0.15 Pain Relevance 0.28
To confirm whether HS+MES promotes insulin receptor phosphorylation, which initiates insulin action by phosphorylating multiple intracellular substrates, we determined the phosphorylation status of IR?
insulin Binding (action) of associated with shock
7) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.26 Pain Relevance 0
We also did not find any association between the Ser1369Ala variant and fasting plasma insulin level or HOMA-B, an indicator for insulin secretion, either at baseline or after gliclazide treatment.
insulin Neg (not) Binding (association) of in plasma
8) Confidence 0.12 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0.41 Pain Relevance 0.05
The hepatic insulin sensitivity index (k/FPG × fasting plasma insulin) was also significantly improved.61
insulin Binding (index) of in plasma
9) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.23 Pain Relevance 0.04
First, it has been reported that serine phosphorylation on Ser302, Ser307, and Ser318 inhibits the association between the insulin receptor and IRS-1 because Ser302 and Ser307 exist near the phosphotyrosine binding domain (155–259), where the insulin receptor binds to IRS-1 (29–31).
insulin Binding (association) of
10) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.35 Pain Relevance 0.03
Pioglitazone is a potent insulin sensitizer, which binds to the peroxisome-proliferator activated receptor-gamma, resulting in enhanced muscle, liver, and adipose tissue sensitivity to insulin, with a resultant decline in fasting and postprandial plasma glucose levels.43–45 Pioglitazone also augments beta cell function46 (Figure 3), reduces inflammation,47 improves endothelial dysfunction,48,49 corrects diabetic dyslipidemia,50 and improves the defect in insulin signaling in muscle, leading to impaired glucose transport/metabolism results in increased generation of nitric oxide (NO).
insulin Binding (binds) of in muscle associated with inflammation, diabetes mellitus and obesity
11) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.90 Pain Relevance 0.04
The ability of insulin to increase glucose uptake by peripheral tissues (primarily muscle) is markedly reduced and this peripheral insulin resistance plays a major role in postprandial hyperglycemia.7,15 Insulin binds to the insulin receptor, resulting in tyrosine phosphorylation both of the insulin receptor and insulin receptor substrate-1 with subsequent activation of phosphoinositol 3 kinase and Akt (Figure 1).
Insulin Binding (binds) of in muscle associated with hyperglycemia and insulin resistance
12) Confidence 0.11 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.90 Pain Relevance 0
Moreover, binding assays with radiolabeled insulin had shown a stronger binding in the ARH compared to the VMH.
insulin Binding (binding) of
13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.28 Pain Relevance 0.06
Moreover, binding assays with radiolabeled insulin had shown a stronger binding in the ARH compared to the VMH.
insulin Binding (binding) of
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.28 Pain Relevance 0.06
negatively regulates insulin and glucose metabolism which may, at least in part, result from an impairment of regular adipose tissue function based on a negative cross-talk between ER?
insulin Binding (metabolism) of in adipose tissue associated with obesity
15) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.03
in insulin and glucose metabolism, the metabolic phenotype of ?
insulin Binding (metabolism) of
16) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.27 Pain Relevance 0
negatively regulates insulin and glucose metabolism which may, at least in part, result from an impairment of regular adipose tissue function based on a negative cross-talk between ER?
insulin Neg (impairment) Binding (result) of in adipose tissue associated with obesity
17) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.34 Pain Relevance 0.03
Key mediators of insulin and glucose metabolism such as the retinol-binding protein 4 (RBP4) were also regulated in ?
insulin Binding (metabolism) of
18) Confidence 0.08 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Thus interactions between insulin, leptin, and glucocorticoids, and the neuropeptide responses they generate within the melanocortin system, allow complex metabolic responses to nutritional status but may also allow the development of metabolic pathologies.


insulin Binding (interactions) of associated with neuropeptide
19) Confidence 0.07 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.41 Pain Relevance 0.05
For the Insulin Tolerance Test (ITT), the mice were fasted for 4 hr (7 am–11 am), and then injected i.p. with recombinant insulin (Humulin, Eli Lily), and their blood glucose levels were measured as above.
insulin Binding (recombinant) of in blood associated with tolerance
20) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.17 Pain Relevance 0.13

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