INT287445

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.59
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Tagln) cytoskeleton organization (Tagln) cytoplasm (Tagln)
Anatomy Link Frequency
muscle 1
smooth muscle cells 1
Tagln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 79.88 Quite High
Inflammation 6 49.00 Quite Low
cva 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 11 99.02 Very High Very High Very High
Cadasil 6 97.96 Very High Very High Very High
Targeted Disruption 7 97.60 Very High Very High Very High
Nervous System Injury 2 96.32 Very High Very High Very High
Stress 6 92.32 High High
Vascular Disease 1 87.72 High High
Alzheimer's Dementia 1 87.28 High High
Atherosclerosis 31 86.76 High High
Leukoencephalopathies 2 85.72 High High
Cv General 4 Under Development 3 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of HCNP may make detrusor muscle supersensitive to acetylcholine and down-regulation of transgelin may decrease its contractility.
Regulation (regulation) of transgelin in muscle associated with overactive bladder
1) Confidence 0.29 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.64 Pain Relevance 0.08
Recently a transgenic mouse model for CADASIL has been developed in which the full-length human Notch3 carrying the Arg90Cys mutation is expressed under the SM22 promoter in vascular smooth muscle cells [90].
Regulation (under) of SM22 in smooth muscle cells associated with targeted disruption and cadasil
2) Confidence 0.26 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.95 Pain Relevance 0

General Comments

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