INT287448

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.73
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Tagln) cytoskeleton organization (Tagln) cytoplasm (Tagln)
Anatomy Link Frequency
bladder 2
smooth muscle cells 1
Tagln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 88.08 High High
Central nervous system 10 74.72 Quite High
Inflammation 14 17.92 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cadasil 6 98.16 Very High Very High Very High
Targeted Disruption 7 97.80 Very High Very High Very High
Lower Urinary Tract Symptoms 30 94.72 High High
Overactive Bladder 55 92.72 High High
Benign Prostatic Hypertrophy 40 90.32 High High
Vascular Disease 1 88.12 High High
Alzheimer's Dementia 1 87.68 High High
Atherosclerosis 31 87.16 High High
Leukoencephalopathies 2 86.12 High High
Cv General 4 Under Development 3 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently a transgenic mouse model for CADASIL has been developed in which the full-length human Notch3 carrying the Arg90Cys mutation is expressed under the SM22 promoter in vascular smooth muscle cells [90].
Gene_expression (expressed) of SM22 in smooth muscle cells associated with targeted disruption and cadasil
1) Confidence 0.65 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 2.01 Pain Relevance 0
Of the changes in protein expression detected in this proteomic analysis, the over-expression of OPTN and the under-expression of transgelin and HCNP were most noteworthy (Fig. 5) (Table 1, 2).


Gene_expression (expression) of transgelin
2) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.44 Pain Relevance 0
In this study, we detected the over-expression of three proteins (OPTN, thioredoxin and preprohaptoglobin), and the under-expression of four proteins (peroxiredoxin 2, transgelin [SM22 alpha], HCNP, and beta-galactoside-binding lectin).
Gene_expression (expression) of SM22 alpha
3) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.31 Pain Relevance 0.08
In this study, we detected the over-expression of three proteins (OPTN, thioredoxin and preprohaptoglobin), and the under-expression of four proteins (peroxiredoxin 2, transgelin [SM22 alpha], HCNP, and beta-galactoside-binding lectin).
Gene_expression (expression) of transgelin
4) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.31 Pain Relevance 0.08
In addition, four proteins, such as peroxiredoxin 2, transgelin, hippocampal cholinergic neurostimulating peptide (HCNP) and beta-galactoside-binding lectin, were under-expressed in the bladder of BOO group.
Gene_expression (expressed) of transgelin in bladder
5) Confidence 0.34 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2779299 Disease Relevance 0.33 Pain Relevance 0
Four proteins (peroxiredoxin 2, transgelin [SM22 alpha], hippocampal cholinergic neurostimulating peptide [HCNP] and beta-galactoside-binding lectin) were under-expressed in the obstructed bladder.
Gene_expression (expressed) of transgelin in bladder
6) Confidence 0.17 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.34 Pain Relevance 0

General Comments

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