INT287482

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIB) signal transduction (NFKBIB) nucleus (NFKBIB)
cytoplasm (NFKBIB) signal transducer activity (NFKBIB)
NFKBIB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 10 58.64 Quite High
cytokine 5 31.60 Quite Low
peripheral neuropathy 12 20.76 Low Low
dexamethasone 46 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 46 94.72 High High
Apoptosis 42 84.48 Quite High
Pancreatic Cancer 21 83.00 Quite High
Cancer 21 82.32 Quite High
Solid Tumor 1 76.04 Quite High
Aggression 2 74.60 Quite High
Adhesions 5 69.52 Quite High
Thrombosis 11 58.64 Quite High
Recurrence 4 37.24 Quite Low
Peripheral Neuropathy 12 20.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P, phosphorylated protein; IkB, nuclear factor kB inhibitory protein
Negative_regulation (inhibitory) of IkB
1) Confidence 0.08 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.50 Pain Relevance 0.03
Studies have shown that PTL targets NF-kB via inhibition of the upstream regulator IkB kinase (IKK) [17] which phosphorylates IkB and targets it for proteasomal degradation.
Negative_regulation (inhibition) of IkB
2) Confidence 0.08 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.89 Pain Relevance 0

General Comments

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