INT287487

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.40
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIB) signal transduction (NFKBIB) nucleus (NFKBIB)
cytoplasm (NFKBIB) signal transducer activity (NFKBIB)
Anatomy Link Frequency
nucleus 1
NFKBIB (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 89 80.48 Quite High
Inflammation 53 62.16 Quite High
cva 10 51.00 Quite High
agonist 7 50.00 Quite Low
cytokine 36 45.68 Quite Low
peripheral neuropathy 12 13.12 Low Low
aspirin 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 46 96.40 Very High Very High Very High
Apoptosis 78 93.36 High High
Adhesions 9 91.80 High High
Cancer 36 89.20 High High
Pancreatic Cancer 42 81.52 Quite High
Solid Tumor 2 74.56 Quite High
Aggression 4 73.12 Quite High
INFLAMMATION 57 62.16 Quite High
Thrombosis 11 51.00 Quite High
Recurrence 4 29.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degradation of IkB by proteasome activates NF-kB, which moves to the nucleus and up-regulates transcription of proteins that promote cell survival and growth, reduce susceptibility to apoptosis, influence the expression of adhesion molecules and induce drug resistance in myeloma cells.
Protein_catabolism (Degradation) of IkB in nucleus associated with apoptosis and adhesions
1) Confidence 0.19 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.59 Pain Relevance 0.03
Studies have shown that PTL targets NF-kB via inhibition of the upstream regulator IkB kinase (IKK) [17] which phosphorylates IkB and targets it for proteasomal degradation.
Protein_catabolism (degradation) of IkB
2) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.84 Pain Relevance 0
Studies have shown that PTL targets NF-kB via inhibition of the upstream regulator IkB kinase (IKK) [17] which phosphorylates IkB and targets it for proteasomal degradation.
Protein_catabolism (degradation) of IkB
3) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.91 Pain Relevance 0
B is the degradation of IkB [33].
Protein_catabolism (degradation) of IkB
4) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.06 Pain Relevance 0.29

General Comments

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