INT287494

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.33
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, CCL2) extracellular region (CRP, CCL2) signal transduction (CCL2)
aging (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
blood 6
macrophage 2
CRP (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 121 97.04 Very High Very High Very High
Inflammation 98 85.16 High High
Inflammatory mediators 4 68.00 Quite High
Angina 6 43.68 Quite Low
Bioavailability 4 23.56 Low Low
alcohol 8 5.68 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 22 96.60 Very High Very High Very High
Atherosclerosis 58 95.04 Very High Very High Very High
Autoimmune Disease 7 86.08 High High
Increased Venous Pressure Under Development 28 85.60 High High
INFLAMMATION 111 85.16 High High
Cardiovascular Disease 26 81.24 Quite High
Bacterial Infection 4 79.76 Quite High
Necrosis 1 69.00 Quite High
Cancer 1 68.64 Quite High
Myocardial Infarction 9 64.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus our studies suggest that human recombinant CRP in the presence of very low levels of endotoxin stimulates IL-6 and MCP-1 production in whole blood.
CRP Positive_regulation (stimulates) of Gene_expression (production) of MCP-1 in blood
1) Confidence 0.30 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.51 Pain Relevance 0.25
In summary, human recombinant CRP with low concentrations of endotoxin stimulated the production of the proatherogenic mediators MCP-1 and IL-6 in human whole blood, but homocysteine did not.
CRP Positive_regulation (stimulated) of Gene_expression (production) of MCP-1 in blood
2) Confidence 0.30 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.15 Pain Relevance 0.15
LPS and recombinant CRP increased IL-6 (Figure 1a) and MCP-1 (Figure 1b) production significantly (all P values < 0.001 compared to saline control).
CRP Positive_regulation (increased) of Gene_expression (production) of MCP-1
3) Confidence 0.28 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.08
Both human recombinant CRP and LPS significantly increased the production of IL-6 and MCP-1 in whole blood samples more than 4-fold (P < 0.001) but homocysteine did not.
CRP Positive_regulation (increased) of Gene_expression (production) of MCP-1 in blood
4) Confidence 0.28 Published 2008 Journal Archives of Drug Information Section Abstract Doc Link PMC2817441 Disease Relevance 0.14 Pain Relevance 0.19
CRP has also proatherogenic properties by being capable of activating the complement system, inducing endothelial production of monocyte chemotactic protein-1(MCP-1) and secretion of endothelin-1 (ET-1) and interleukin 6 (IL-6), up regulating adhesion molecules (ICAM-1, VCAM-1, selectins), mediating macrophage uptake of LDL and stimulating monocyte production of tissue factor [7, 17-19].
CRP Positive_regulation (inducing) of Gene_expression (production) of monocyte chemotactic protein-1 in macrophage associated with adhesions
5) Confidence 0.22 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779351 Disease Relevance 1.53 Pain Relevance 0.15

General Comments

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