INT287500

Context Info Confidence 0.09 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.47 Pain Relevance 0.12

plasma membrane (Prx) nucleus (Prx) cytoplasm (Prx)

Anatomy Link Frequency lung 1 Prx (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 9 69.36 Inflammation 19 69.00 cva 6 52.96 ischemia 31 5.00 anesthesia 9 5.00 Inflammatory response 7 5.00 metalloproteinase 5 5.00 Catecholamine 4 5.00 Central nervous system 3 5.00 Inflammatory mediators 3 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 19 85.24 Lung Injury 38 73.48 INFLAMMATION 29 69.00 Endotoxemia 1 65.24 Cv General 3 Under Development 6 52.96 Brain Injury 21 40.68 Pressure And Volume Under Development 9 38.64 Injury 35 37.48 Hypothermia 24 5.00 Coronary Heart Disease 21 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The change in Prx II level in response to the treatment with doxycycline, observed in this study, could be an important defense mechanism limiting peroxynitrite-dependent lung damage during mechanical ventilation.

Regulation (change) of Prx in lung

1) Confidence 0.09 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.33 Pain Relevance 0.10

The PRx and Mx were the first continuous indices of autoregulation that detect the passive transmission of spontaneous waves of CPP to CBF surrogates.

Regulation (autoregulation) of PRx

2) Confidence 0.01 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2779352 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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