INT287526

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 4.25
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 154 100.00 Very High Very High Very High
Calcium channel 4 93.52 High High
headache 20 86.24 High High
sodium channel 2 68.08 Quite High
Nav1.1 2 66.80 Quite High
hyperexcitability 2 10.32 Low Low
Dopamine 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
drug abuse 6 5.00 Very Low Very Low Very Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 60 100.00 Very High Very High Very High
Headache 130 96.40 Very High Very High Very High
Epilepsy 8 89.88 High High
Hemiplegia 2 89.20 High High
Paresis 2 88.64 High High
Headache Disorders 4 80.88 Quite High
Adverse Drug Reaction 4 60.56 Quite High
Convulsion 2 48.00 Quite Low
Neurological Disease 2 40.24 Quite Low
Ataxia 2 33.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in three different genes have been identified in FHM families: CACNA1A gene, involved in FHM type 1 (FHM1), localised to chromosome 19p13, encoding for the ?
Negative_regulation (identified) of Gene_expression (families) of FHM associated with migraine
1) Confidence 0.42 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 2.10 Pain Relevance 1.87
Mutations in three different genes have been identified in FHM families: CACNA1A gene, involved in FHM type 1 (FHM1), localised to chromosome 19p13, encoding for the ?
Negative_regulation (localised) of Gene_expression (gene) of CACNA1A associated with migraine
2) Confidence 0.42 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 2.15 Pain Relevance 1.94

General Comments

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