INT287529

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.10
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (AKR1B1) carbohydrate metabolic process (AKR1B1) response to stress (AKR1B1)
cytoplasm (AKR1B1) cytosol (AKR1B1) extracellular space (AKR1B1)
AKR1B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 10 99.08 Very High Very High Very High
Migraine 77 93.00 High High
Inflammation 29 50.00 Quite Low
cytokine 16 33.52 Quite Low
Inflammatory response 2 29.12 Quite Low
headache 10 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine Without Aura 10 99.80 Very High Very High Very High
Hyperglycemia 38 99.48 Very High Very High Very High
Stress 32 97.78 Very High Very High Very High
Headache 65 93.00 High High
Diabetes Mellitus 84 85.80 High High
Migraine With Aura 30 83.60 Quite High
Injury 5 72.80 Quite High
Apoptosis 90 71.84 Quite High
Disease 16 64.44 Quite High
INFLAMMATION 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However once patients were divided into subgroups, MO patients presented a significant increase of the HLADRB* 16 allele.
Negative_regulation (presented) of Positive_regulation (increase) of ADR associated with migraine without aura
1) Confidence 0.41 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 1.30 Pain Relevance 0.58
Oxidative stress is probably a key event in endothelial dysfunction since inhibition of hyperglycemia, induced, ROS production prevents activation of the aldose reductase, hexosamine pathways, PKC activation, and AGE formation [77, 89].
Negative_regulation (prevents) of Positive_regulation (activation) of aldose reductase associated with hyperglycemia, stress and kinase c
2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.80 Pain Relevance 0.05

General Comments

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