INT287566

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.94
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sar1b) vesicle-mediated transport (Sar1b) Golgi apparatus (Sar1b)
endoplasmic reticulum (Sar1b) intracellular (Sar1b)
Anatomy Link Frequency
myocardium 1
testes 1
cortex 1
intestine 1
cerebellum 1
Sar1b (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 8 99.52 Very High Very High Very High
Pain 10 39.84 Quite Low
Action potential 3 26.24 Quite Low
agonist 28 5.00 Very Low Very Low Very Low
fibrosis 24 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 270 99.32 Very High Very High Very High
Coronary Heart Disease 12 99.08 Very High Very High Very High
Appetite Loss 15 98.32 Very High Very High Very High
Congenital Anomalies 48 95.44 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 3 90.84 High High
Diarrhoea 30 84.00 Quite High
Syndrome 18 81.44 Quite High
Necrosis 3 57.32 Quite High
Fragile X Syndrome 84 50.00 Quite Low
Cramps 3 40.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Sar1b GTPase is expressed not only in the intestine but also in the liver, muscle and brain.
Gene_expression (expressed) of Sar1b in intestine
1) Confidence 0.47 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 0.87 Pain Relevance 0
This suggests that the recent description of cardiomyopathy in CRD may be related to the tissue-specific expression of abnormal Sar1b protein.
Gene_expression (expression) of Sar1b associated with coronary heart disease and disorder of lipid metabolism
2) Confidence 0.47 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.25 Pain Relevance 0
Furthermore, the myocardium has been shown to express the Sar1b gene and secrete apo B lipoproteins [37,38].
Gene_expression (express) of Sar1b gene in myocardium associated with disorder of lipid metabolism
3) Confidence 0.47 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.13 Pain Relevance 0
Histologic analysis of cerebellum, cortex, hippocampus and testes revealed no defects (Figure S1A, S1B, S1C, S1D, S1E, S1F, S1G, S1H, S1I, SIJ, S1K, S1L, S1M, S1N, S1O, S1P), similar to Fmr1 null mice [53],[54].
Neg (no) Gene_expression (defects) of S1B in testes associated with hippocampus
4) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.17 Pain Relevance 0.05
Histologic analysis of cerebellum, cortex, hippocampus and testes revealed no defects (Figure S1A, S1B, S1C, S1D, S1E, S1F, S1G, S1H, S1I, SIJ, S1K, S1L, S1M, S1N, S1O, S1P), similar to Fmr1 null mice [53],[54].
Neg (no) Gene_expression (defects) of S1B in cortex associated with hippocampus
5) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.17 Pain Relevance 0.05
Histologic analysis of cerebellum, cortex, hippocampus and testes revealed no defects (Figure S1A, S1B, S1C, S1D, S1E, S1F, S1G, S1H, S1I, SIJ, S1K, S1L, S1M, S1N, S1O, S1P), similar to Fmr1 null mice [53],[54].
Neg (no) Gene_expression (defects) of S1B in hippocampus associated with hippocampus
6) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.17 Pain Relevance 0.05
Histologic analysis of cerebellum, cortex, hippocampus and testes revealed no defects (Figure S1A, S1B, S1C, S1D, S1E, S1F, S1G, S1H, S1I, SIJ, S1K, S1L, S1M, S1N, S1O, S1P), similar to Fmr1 null mice [53],[54].
Neg (no) Gene_expression (defects) of S1B in cerebellum associated with hippocampus
7) Confidence 0.00 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.17 Pain Relevance 0.05

General Comments

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