INT287567

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Fmr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 14 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 74.80 Quite High
Fragile X Syndrome 42 68.72 Quite High
Disease 18 28.56 Quite Low
Intellectual Impairment 18 5.00 Very Low Very Low Very Low
Liver Disease 10 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Autism 8 5.00 Very Low Very Low Very Low
Convulsion 8 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests that loss of FMRP activity, including but not necessarily limited to KH2 RNA binding, may play a critical role in leading to the synaptic defects evident in the mouse, and, presumably, in human patients.
Neg (not) Negative_regulation (limited) of Negative_regulation (loss) of FMRP
1) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Therefore a major biochemical defect in the Fmr1I304N mouse is the loss of KH2-dependent RNA binding.
Negative_regulation (loss) of Negative_regulation (defect) of Fmr1I304N
2) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.14 Pain Relevance 0

General Comments

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