INT287577

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.50
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Fmr1 (Mus musculus)
Fmr1 - I304N (1)
Pain Link Frequency Relevance Heat
Fibrositis 10 85.76 High High
Multiple sclerosis 10 85.00 Quite High
Central nervous system 6 64.40 Quite High
withdrawal 8 40.00 Quite Low
depression 9 38.08 Quite Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Electroencephalography 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 99.88 Very High Very High Very High
Autoimmune Disease 134 98.46 Very High Very High Very High
Syndrome 159 96.20 Very High Very High Very High
Macrocephaly 6 90.84 High High
Tics 42 90.28 High High
Convulsion 88 89.40 High High
Sleep Disorders 10 85.76 High High
Demyelinating Disease 10 85.00 Quite High
Systemic Lupus Erythematosus 10 84.04 Quite High
Thyroid Disease 14 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Univariate analysis of continuous variables including age, CGG repeat size, FMR1 mRNA level, activation ratio (AR: the fraction of normal FMR1 allele as the active allele in female individuals with FXS), IQ, and adaptive functioning was based on t test.
Positive_regulation (activation) of Transcription (level) of FMR1 associated with syndrome
1) Confidence 0.48 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 0.72 Pain Relevance 0
These autoimmune disorders in some premutation carriers are thought to be related to RNA toxicity from elevated levels of FMR1 mRNA (Coffey et al. 2008; Greco et al. 2008; Zhang et al. 2009).
Positive_regulation (elevated) of Transcription (levels) of FMR1 associated with toxicity and autoimmune disease
2) Confidence 0.45 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.65 Pain Relevance 0.16
However, we find no evidence to support the consequent prediction that in the I304N mouse there would be an increase in translation of the I304N-Fmr1 mRNA.
Positive_regulation (increase) of Transcription (translation) of I304N-Fmr1 (I304N)
3) Confidence 0.44 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

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