INT287587

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fmr1) RNA binding (Fmr1) nucleus (Fmr1)
cytoplasm (Fmr1)
Fmr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 98.40 Very High Very High Very High
agonist 7 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 96.18 Very High Very High Very High
Sprains And Strains 2 86.60 High High
Anxiety Disorder 5 77.96 Quite High
Convulsion 4 73.36 Quite High
Targeted Disruption 9 65.20 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Neurological Disease 1 42.12 Quite Low
Glycogen Storage Disease 2 19.32 Low Low
Liver Disease 5 18.16 Low Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, our behavioral assays of Fmr1I304N mice indicate that they show abnormalities in the same tests, in the same direction, and to similar levels in all assays previously performed in our laboratory (Table 1), strongly supporting the conclusion that the I304N mutation is sufficient to phenocopy loss of the Fmr1 gene.
Regulation (sufficient) of Negative_regulation (loss) of Fmr1 associated with congenital anomalies
1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.46 Pain Relevance 0.05

General Comments

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