INT287593

Context Info Confidence 0.45 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0 Pain Relevance 0

cytoplasm (Fxr2)

Anatomy Link Frequency brain 2 Fxr2 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 28 5.00 Glutamate receptor 8 5.00 Hippocampus 8 5.00 depression 4 5.00 Pain 4 5.00 nMDA receptor antagonist 4 5.00 alcohol 4 5.00 Immobilon 4 5.00 isoflurane 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Fragile X Syndrome 84 50.00 Liver Disease 20 28.76 Intellectual Impairment 36 15.36 Targeted Disruption 36 5.00 Disease 36 5.00 Li-fraumeni Syndrome 20 5.00 Anxiety Disorder 20 5.00 Autism 16 5.00 Convulsion 16 5.00 Syndrome 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also found that the I304N mutation in FMRP does not significantly affect FXR1P or FXR2P polyribosome association in mouse brain (Figure 5A), suggesting that their polysome-association is not FMRP-dependent.

FXR2P Neg (not) Binding (association) of in brain

1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0

This is consistent with our observation that I304N-FMRP in mouse brain fails to crosslink to kcRNA, but retains other activities, including the ability to crosslink to G-quartet RNA and to heterodimerize with FXR1P and FXR2P (Figure 7).

FXR2P Binding (heterodimerize) of in brain

2) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0

In vitro studies indicated that I304N FMRP retains the ability to heterodimerize with FXR1P and FXR2P [63].

FXR2P Binding (heterodimerize) of

3) Confidence 0.34 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0

Protein interaction domains include an N-terminal region responsible for homodimerization and heterodimerization with its autosomal homologs FXR1P and FXR2P [45],[46].

FXR2P Binding (heterodimerization) of

4) Confidence 0.34 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0

General Comments

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