INT287593

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Fxr2)
Anatomy Link Frequency
brain 2
Fxr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 28 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fragile X Syndrome 84 50.00 Quite Low
Liver Disease 20 28.76 Quite Low
Intellectual Impairment 36 15.36 Low Low
Targeted Disruption 36 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 20 5.00 Very Low Very Low Very Low
Anxiety Disorder 20 5.00 Very Low Very Low Very Low
Autism 16 5.00 Very Low Very Low Very Low
Convulsion 16 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that the I304N mutation in FMRP does not significantly affect FXR1P or FXR2P polyribosome association in mouse brain (Figure 5A), suggesting that their polysome-association is not FMRP-dependent.
FXR2P Neg (not) Binding (association) of in brain
1) Confidence 0.45 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
This is consistent with our observation that I304N-FMRP in mouse brain fails to crosslink to kcRNA, but retains other activities, including the ability to crosslink to G-quartet RNA and to heterodimerize with FXR1P and FXR2P (Figure 7).
FXR2P Binding (heterodimerize) of in brain
2) Confidence 0.35 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
In vitro studies indicated that I304N FMRP retains the ability to heterodimerize with FXR1P and FXR2P [63].
FXR2P Binding (heterodimerize) of
3) Confidence 0.34 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0
Protein interaction domains include an N-terminal region responsible for homodimerization and heterodimerization with its autosomal homologs FXR1P and FXR2P [45],[46].
FXR2P Binding (heterodimerization) of
4) Confidence 0.34 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0 Pain Relevance 0

General Comments

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