INT287594

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Pkn1) signal transduction (Pkn1) histone binding (Pkn1)
cytoplasmic membrane-bounded vesicle (Pkn1) plasma membrane (Pkn1) nucleus (Pkn1)
Pkn1 (Mus musculus)
Pkn1 - I304N (1)
Pain Link Frequency Relevance Heat
agonist 7 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 2 62.20 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Targeted Disruption 9 38.84 Quite Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Liver Disease 5 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low
Autism 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, it seems most likely that the observed decrease in I304N protein levels is due to increased turnover of the mutant protein.
Negative_regulation (decrease) of I304N protein (I304N)
1) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.12 Pain Relevance 0

General Comments

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