INT287676

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Sphk1, Pik3r1) cytosol (Sphk1, Pik3r1) nucleus (Sphk1, Pik3r1)
plasma membrane (Sphk1, Pik3r1) kinase activity (Sphk1, Pik3r1) intracellular (Pik3r1)
Sphk1 (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 31 75.00 Quite High
Disease 3 57.28 Quite High
Cancer 29 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Recurrence 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, inhibition of the PI3K/Akt pathway¬óby negatively impacting SphK1 activity¬ócould prevent NE differentiation in both cell models, an event that could be mimicked by SphK1 inhibitors.
Negative_regulation (impacting) of SphK1 Negative_regulation (inhibition) of PI3K
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779655 Disease Relevance 0.42 Pain Relevance 0

General Comments

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