INT287690

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) intracellular (Parp1)
DNA binding (Parp1) protein complex (Parp1) nucleolus (Parp1)
Anatomy Link Frequency
poly 2
Parp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 50 92.72 High High
Inflammation 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 46 92.72 High High
Brain Hemorrhage 3 50.00 Quite Low
Infarction 1 46.56 Quite Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Stroke 10 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with 3-AB produced an important decrease in PAR immunostaining at 4 h and resulted in an almost disappearance of poly(ADP-ribose) at 24 h (Fig. 3A), which demonstrates a reduced capacity for PARP-1 activation in 3-AB treated animals and validates our pharmacological treatment.
Negative_regulation (reduced) of Positive_regulation (activation) of PARP-1 in poly
1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.65 Pain Relevance 0.33

General Comments

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