INT28770

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 4.95
Pain Relevance 12.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
pallidum 6
spinal 2
U-937 2
blood 2
arcuate nucleus 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 76 100.00 Very High Very High Very High
Enkephalin 59 100.00 Very High Very High Very High
Kappa opioid receptor 25 100.00 Very High Very High Very High
opioid receptor 9 100.00 Very High Very High Very High
Endogenous opioid 4 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Hyperalgesia 7 99.90 Very High Very High Very High
cocaine 17 99.36 Very High Very High Very High
Cancer pain 5 99.32 Very High Very High Very High
electroacupuncture 9 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 8 99.90 Very High Very High Very High
Cancer 4 99.48 Very High Very High Very High
Cancer Pain 4 99.32 Very High Very High Very High
Pain 77 98.16 Very High Very High Very High
Endometriosis (extended) 9 97.24 Very High Very High Very High
Reprotox - General 1 7 96.72 Very High Very High Very High
Parkinson's Disease 12 94.44 High High
Cocaine Dependence 3 91.56 High High
Frailty 58 89.08 High High
Hypertrophy 3 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model.
Negative_regulation (inhibits) of Gene_expression (expression) of preprodynorphin in spinal associated with hyperalgesia, cancer and electroacupuncture
1) Confidence 0.57 Published 2008 Journal Eur J Pain Section Title Doc Link 18221900 Disease Relevance 1.13 Pain Relevance 1.18
Given the inhibitory effect of dynorphin on the reproductive axis, decreased dynorphin gene expression could play a role in the elevation in luteinising hormone secretion that occurs in postmenopausal women.
Negative_regulation (decreased) of Gene_expression (expression) of dynorphin gene associated with dynorphin
2) Confidence 0.55 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.19 Pain Relevance 0.21
To inhibit the blocking function of the DREAM protein on pdyn gene expression in SFLCs, five T7 siRNAs were designed and tested (Figure 3a).
Negative_regulation (inhibit) of Gene_expression (expression) of pdyn
3) Confidence 0.53 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.76 Pain Relevance 0.60
The number of dynorphin mRNA-expressing neurones was also reduced in the medial preoptic/anterior hypothalamic area of postmenopausal women without changes in cell size.
Negative_regulation (reduced) of Gene_expression (expressing) of dynorphin mRNA in anterior associated with dynorphin
4) Confidence 0.48 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.20 Pain Relevance 0.28
In order to test the role of transcription in LPS-mediated down-regulation of PDYN gene expression in U937 cells, the proximal PDYN gene promoter with a length of either approximately 300 base pairs or approximately 900 base pairs was cloned and inserted upstream of luciferase reporter gene.
Negative_regulation (down-regulation) of Gene_expression (expression) of PDYN gene in proximal
5) Confidence 0.43 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16483672 Disease Relevance 0 Pain Relevance 0.13
The expression of prodynorphin gene is down-regulated by activation with lipopolysaccharide in U-937 macrophage cells.
Negative_regulation (down-regulated) of Gene_expression (expression) of prodynorphin in U-937 associated with enkephalin
6) Confidence 0.43 Published 2006 Journal J. Neuroimmunol. Section Title Doc Link 16483672 Disease Relevance 0 Pain Relevance 0.39
Moreover, ovariectomy decreases the expression of prodynorphin gene transcripts in the arcuate nucleus of the ewe.
Negative_regulation (decreases) of Gene_expression (expression) of prodynorphin in arcuate nucleus
7) Confidence 0.40 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.34 Pain Relevance 0.14
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of Gene_expression (levels) of Met5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
8) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of Gene_expression (levels) of Leu5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
9) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
To inhibit the blocking function of the DREAM protein on pdyn gene expression in SFLCs, five T7 siRNAs were designed and tested (Figure 3a).
Negative_regulation (blocking) of Gene_expression (expression) of pdyn
10) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.76 Pain Relevance 0.60
In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process.
Spec (examined) Negative_regulation (desensitization) of Gene_expression (produced) of Leu-enkephalin associated with endogenous opioid, enkephalin and opioid receptor
11) Confidence 0.33 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.77
Dynorphin gene expression, dynorphin peptides, and kappa-opioid receptor gene expression and binding have been shown to be altered in response to cocaine administration.
Negative_regulation (altered) of Gene_expression (expression) of Dynorphin gene associated with dynorphin, kappa opioid receptor and cocaine
12) Confidence 0.26 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862779 Disease Relevance 0.07 Pain Relevance 1.36
Entry of [3H]Leu-enkephalin was not inhibited in the presence of either a 5 mM concentration of unlabelled L-tyrosine, tyrosylglycine, and tyrosylglycylglycine, or aminopeptidase inhibitor, bestatin (0.5 mM), suggesting that the saturable mechanism of the tracer at the luminal side of the blood-brain barrier does not involve uptake of the peptide's N-terminal amino acid and/or its tyrosine-containing fragments.
Negative_regulation (inhibited) of Gene_expression (Entry) of Leu-enkephalin in blood associated with enkephalin
13) Confidence 0.24 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2795003 Disease Relevance 0 Pain Relevance 0.50
Dynorphin gene expression, dynorphin peptides, and kappa-opioid receptor gene expression and binding have been shown to be altered in response to cocaine administration.
Negative_regulation (altered) of Gene_expression (expression) of dynorphin associated with dynorphin, kappa opioid receptor and cocaine
14) Confidence 0.23 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862779 Disease Relevance 0.07 Pain Relevance 1.35
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of in putamen Gene_expression (levels) of Met5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
15) Confidence 0.14 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of in putamen Gene_expression (levels) of Leu5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
16) Confidence 0.14 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction.
Negative_regulation (disruption) of Gene_expression (expression) of dynorphin gene associated with addiction, dynorphin, kappa opioid receptor and cocaine
17) Confidence 0.06 Published 1996 Journal J Addict Dis Section Abstract Doc Link 8943583 Disease Relevance 0.38 Pain Relevance 1.17
H-Gly-Phe-OMe at single concentrations (1-10 microM) significantly decreased the maximum inhibition produced by cumulatively added (0.1 nM-100 microM) morphine, Met-enkephalin or Leu-enkephalin.
Negative_regulation (inhibition) of Gene_expression (produced) of Leu-enkephalin associated with enkephalin and morphine
18) Confidence 0.04 Published 1994 Journal Gen. Pharmacol. Section Abstract Doc Link 8026730 Disease Relevance 0 Pain Relevance 1.36

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