INT287726

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Context Info
Confidence 0.76
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.89
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar3) plasma membrane (Lpar3) signal transducer activity (Lpar3)
Anatomy Link Frequency
epithelial cells 2
cerebrospinal fluid 1
neurons 1
astrocytes 1
Lpar3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 352 99.84 Very High Very High Very High
intrathecal 45 98.76 Very High Very High Very High
Sciatic nerve 72 93.44 High High
Pain 67 92.32 High High
dorsal root ganglion 13 91.28 High High
allodynia 47 91.20 High High
Neuropathic pain 116 90.84 High High
Thermal hyperalgesia 18 90.20 High High
spinal dorsal horn 45 89.12 High High
Demyelination 38 81.68 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 52 99.86 Very High Very High Very High
Urological Neuroanatomy 45 93.16 High High
Ganglion Cysts 86 92.96 High High
Pain 67 92.32 High High
Neuropathic Pain 163 91.20 High High
Hyperalgesia 45 90.20 High High
Nociception 29 88.48 High High
Demyelinating Disease 49 81.68 Quite High
Nervous System Injury 18 75.00 Quite High
Cancer 24 38.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to previous reports, the LPA3 gene in mice is expressed in astrocytes, but not microglias [44-46].
Neg (not) Gene_expression (expressed) of LPA3 gene in astrocytes
1) Confidence 0.76 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.53 Pain Relevance 0.38
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Gene_expression (express) of LPA3 in epithelial cells associated with ovarian cancer
2) Confidence 0.76 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.45 Pain Relevance 0.34
ATX and LPA3 receptors are required in LPC-induced LPA production
Gene_expression (receptors) of LPA3
3) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.19 Pain Relevance 0.35
Similar time-related and LPA3 receptor-mediated production of LPA was observed following intrathecal administration of LPA.
Gene_expression (production) of LPA3 receptor associated with intrathecal
4) Confidence 0.59 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2780384 Disease Relevance 0.39 Pain Relevance 0.58
There are currently no reports detailing the expression of the LPA3 receptor in mouse neurons.
Gene_expression (expression) of LPA3 receptor in neurons
5) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.58 Pain Relevance 0.41
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Gene_expression (express) of LPA3 in epithelial cells associated with ovarian cancer
6) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.47 Pain Relevance 0.35
Finally, it should be noted that LPA-induced de novo LPC (or converted LPA) synthesis in SC and DR was completely absent in Lpar3-/- mice, but not in Lpar1-/- and Lpar2-/- mice, though LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR.
Gene_expression (expressed) of LPA3 associated with spinal cord
7) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.45 Pain Relevance 0.38
Recently, Ueda et al. proposed a feed-forward loop that involves LPA3 receptor-mediated production of lysophosphatidylcholine, which supplies the substrate to ATX, rich in the cerebrospinal fluid.
Gene_expression (production) of LPA3 receptor in cerebrospinal fluid
8) Confidence 0.30 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.78 Pain Relevance 0.62
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Gene_expression (production) of LPA3
9) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.28
On the other hand, three kinds of LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR by RT-PCR, though the level of LPA1 transcripts was much higher than the others (Additional file 2; Fig.
Gene_expression (expressed) of LPA3 associated with spinal cord
10) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.05 Pain Relevance 0.43

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