INT287727

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 0.55
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dmbx1) DNA binding (Dmbx1)
Anatomy Link Frequency
neurons 1
Dmbx1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 426 99.76 Very High Very High Very High
addiction 12 96.28 Very High Very High Very High
antagonist 28 88.44 High High
tetrodotoxin 78 85.96 High High
agonist 63 84.80 Quite High
Potency 29 77.24 Quite High
Inflammation 9 68.92 Quite High
Dorsal horn 5 44.24 Quite Low
Spinal cord 40 40.56 Quite Low
Neuropathic pain 21 32.48 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 30 90.80 High High
Skin Cancer 5 78.64 Quite High
Cancer 92 73.92 Quite High
Contact Dermatitis 6 70.08 Quite High
INFLAMMATION 10 68.92 Quite High
Embryonic Lethality 4 54.32 Quite High
Neuroblastoma 26 53.60 Quite High
Metastasis 67 50.00 Quite Low
Nervous System Injury 2 50.00 Quite Low
Ganglion Cysts 14 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct evidence for ATX interaction with VGSC was derived from the demonstration of stimulation of [3H]batrachotoxin binding and sodium influx by ATX in cultured neurons [11,12].
ATX Binding (interaction) of in neurons associated with sodium channel
1) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0.34 Pain Relevance 0.59
Recombinant ATX
ATX Binding (Recombinant) of
2) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0
scorpion toxin interaction with neurotoxin site 4, ATX may interact preferentially with the inactivated state of VGSC ?
ATX Binding (interact) of associated with sodium channel
3) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.15
It is also possible that ATX may interact preferentially with the inactivated state of VGSC ?
ATX Binding (interact) of associated with sodium channel
4) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.25
ATX binds to a site on the sodium channel ?
ATX Binding (binds) of associated with sodium channel
5) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.33
ATX binds to an undefined site on the sodium channel ?
ATX Spec (undefined) Binding (binds) of associated with sodium channel
6) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.15
Our results indicate that ATX acts by binding to the ?
ATX Binding (binding) of
7) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.24
The cDNAs were amplified by PCR for 35 cycles with the following specific PCR primers: human ATX, 5?
ATX Binding (amplified) of
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0 Pain Relevance 0
In extracellular biological fluids, LPA production is linked to ATX, which is a lysophospholipase D that cleaves the headgroup from lysophospholipids to generate LPA.
ATX Binding (linked) of
9) Confidence 0.07 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.21 Pain Relevance 0

General Comments

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