INT287729

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.96
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Anatomy Link Frequency
4T1 1
skeletal muscle 1
brain 1
lung 1
placenta 1
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 43 99.22 Very High Very High Very High
spinal dorsal horn 5 90.40 High High
Potency 14 61.80 Quite High
Sciatic nerve 8 47.28 Quite Low
agonist 60 43.56 Quite Low
Dorsal horn 8 23.36 Low Low
antagonist 61 5.00 Very Low Very Low Very Low
Neuropathic pain 45 5.00 Very Low Very Low Very Low
fibrosis 36 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 97 95.64 Very High Very High Very High
Cancer 164 93.60 High High
Breast Cancer 58 86.40 High High
Alopecia 12 79.08 Quite High
Targeted Disruption 64 67.04 Quite High
Nervous System Injury 2 50.00 Quite Low
Urological Neuroanatomy 5 47.00 Quite Low
Ganglion Cysts 29 46.80 Quite Low
Ovarian Cancer 71 5.00 Very Low Very Low Very Low
Apoptosis 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Firstly, we found that 4T1 cells expressed the mRNA of all forms of LPA receptors and responded to LPA stimulation (Figure 4A and 4B).
Transcription (expressed) of LPA in 4T1
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.85 Pain Relevance 0.03
On the other hand, three kinds of LPA1, LPA2 and LPA3 receptors were all expressed in SC and DR by RT-PCR, though the level of LPA1 transcripts was much higher than the others (Additional file 2; Fig.
Transcription (transcripts) of LPA1 associated with spinal cord
2) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.40
Transcripts for this putative LPA receptor were detected in the uterus, prostate, brain, lung, placenta and skeletal muscle.
Transcription (detected) of LPA receptor in placenta
3) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.28 Pain Relevance 0
Transcripts for this putative LPA receptor were detected in the uterus, prostate, brain, lung, placenta and skeletal muscle.
Transcription (detected) of LPA receptor in brain
4) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.28 Pain Relevance 0
Transcripts for this putative LPA receptor were detected in the uterus, prostate, brain, lung, placenta and skeletal muscle.
Transcription (detected) of LPA receptor in lung
5) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.28 Pain Relevance 0
Transcripts for this putative LPA receptor were detected in the uterus, prostate, brain, lung, placenta and skeletal muscle.
Transcription (detected) of LPA receptor in skeletal muscle
6) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.28 Pain Relevance 0

General Comments

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