INT287735

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.60
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dmbx1) DNA binding (Dmbx1)
Anatomy Link Frequency
lymphocytes 3
plasma 2
dorsal root 2
T cell 1
Dmbx1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 7 99.60 Very High Very High Very High
Demyelination 98 99.28 Very High Very High Very High
sodium channel 71 95.68 Very High Very High Very High
Spinal cord 49 94.80 High High
metalloproteinase 30 94.00 High High
Sciatic nerve 52 93.76 High High
Neuropathic pain 87 86.12 High High
Dorsal horn 12 69.84 Quite High
dorsal root ganglion 36 51.72 Quite High
spinal dorsal horn 8 51.00 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 14 99.76 Very High Very High Very High
Ovarian Cancer 116 99.60 Very High Very High Very High
Cv General 3 Under Development 7 99.60 Very High Very High Very High
Demyelinating Disease 118 99.28 Very High Very High Very High
Disease 50 98.88 Very High Very High Very High
Cancer 168 97.32 Very High Very High Very High
Targeted Disruption 105 95.32 Very High Very High Very High
Breast Cancer 21 94.88 High High
Embryonic Lethality 28 94.68 High High
Apoptosis 105 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATX and LPA3 receptors are required in LPC-induced LPA production
Positive_regulation (required) of Gene_expression (receptors) of ATX
1) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.19 Pain Relevance 0.35
M) in the presence of ATX (30 ng/ml) markedly increases the incidence of demyelination of dorsal roots to 35% of total myelinated fibers, being equivalent to the level of ex vivo dorsal root demyelination by LPA (1 ?
Positive_regulation (increases) of Gene_expression (presence) of ATX in dorsal root associated with demyelination
2) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.40 Pain Relevance 0.70
The ability of ATX to stimulate sodium influx in these cell lines is, however, clearly not dependent on the expression of the VGSC ?
Positive_regulation (ability) of Gene_expression (ability) of ATX associated with sodium channel
3) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009643 Disease Relevance 0 Pain Relevance 0.38
Ovarian cancer ascites has highly elevated levels of LPA (Xu et al., 1995; Baker et al., 2002; Sutphen et al., 2004) due to increased ATX expression (Dimova et al., 2006).
Positive_regulation (increased) of Gene_expression (expression) of ATX associated with pressure and volume under development and ovarian cancer
4) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.47 Pain Relevance 0.06
In adult mice, ATX overexpression leads to haemorrhages due to an inhibitory effect of LPA on platelets, whereas ATX ± heterozygotes, which have a reduced plasma LPA concentration, are more prone to thrombosis (Pamuklar et al., 2009).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ATX in plasma associated with cva and thrombosis
5) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.46 Pain Relevance 0.05
Lipopolysaccharide treatment of TH-1 lymphocytes increases ATX expression that can supply LPA upon contact of the T cell with other immune cells (Li and Zhang, 2009).
Positive_regulation (increases) of Gene_expression (expression) of ATX in lymphocytes
6) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.13 Pain Relevance 0
ATX is overexpressed in patients with recurrent disease after prior treatment with chemotherapy (Jazaeri et al., 2005).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ATX associated with disease
7) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.48 Pain Relevance 0
Ovarian cancer ascites has highly elevated levels of LPA (Xu et al., 1995; Baker et al., 2002; Sutphen et al., 2004) due to increased ATX expression (Dimova et al., 2006).
Positive_regulation (elevated) of Gene_expression (expression) of ATX associated with pressure and volume under development and ovarian cancer
8) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.53 Pain Relevance 0.09
Lipopolysaccharide treatment of TH-1 lymphocytes increases ATX expression that can supply LPA upon contact of the T cell with other immune cells (Li and Zhang, 2009).
Positive_regulation (supply) of in T cell Gene_expression (expression) of ATX in lymphocytes
9) Confidence 0.09 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.13 Pain Relevance 0
LPA increases VEGF production, and VEGF in turn up-regulates ATX production, which increases LPA levels (Ptaszynska et al., 2008) – a potential feed-forward loop.
Positive_regulation (increases) of Gene_expression (production) of ATX
10) Confidence 0.08 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.82 Pain Relevance 0.09

General Comments

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