INT287736

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.66
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar3) plasma membrane (Lpar3) signal transducer activity (Lpar3)
Anatomy Link Frequency
embryo 1
epithelial cells 1
OVCAR-3 1
Lpar3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 158 96.24 Very High Very High Very High
allodynia 24 90.68 High High
Thermal hyperalgesia 8 89.68 High High
Hyperalgesia 12 89.40 High High
agonist 30 87.36 High High
spinal dorsal horn 20 73.36 Quite High
antagonist 30 62.08 Quite High
Central nervous system 4 42.32 Quite Low
Neuropathic pain 64 19.36 Low Low
Sciatic nerve 32 14.48 Low Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 48 99.60 Very High Very High Very High
Cancer 48 98.84 Very High Very High Very High
Targeted Disruption 30 97.64 Very High Very High Very High
Aggression 4 94.36 High High
Metastasis 20 91.76 High High
Neuropathic Pain 88 90.68 High High
Hyperalgesia 20 89.68 High High
Nociception 16 87.60 High High
Malignant Neoplastic Disease 4 82.00 Quite High
Placenta Previa 2 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPA-induced LPA production was also entirely absent in Lpar3-/- mice (Fig. 3c and 3d).


Positive_regulation (absent) of Lpar3
1) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.31
Here we demonstrated for the first time that i.t. injected LPC is not only converted to LPA through an action of endogenous ATX, but also causes a new synthesis of LPA in vivo in a feed-forward manner through the LPA3 receptor.
Positive_regulation (causes) of LPA3 receptor
2) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.50 Pain Relevance 0.54
In a study with 30 ovarian cancer patients, LPA1 expression was decreased, whereas LPA2 and LPA3 were increased (Murph et al., 2008) in the tumour tissue. siRNA-mediated knock-down of LPA2 and LPA3 in SKOV and OVCAR-3 ovarian cancer cell lines reduced aggressiveness and increased survival after xenografting (Yu et al., 2008).


Positive_regulation (increased) of LPA3 in OVCAR-3 associated with targeted disruption, cancer, aggression and ovarian cancer
3) Confidence 0.34 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.44 Pain Relevance 0.11
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Positive_regulation (levels) of LPA3 in epithelial cells associated with ovarian cancer
4) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.47 Pain Relevance 0.35
The LPA3 receptor, which is up-regulated by progesterone and down-regulated by oestrogen, is required for embryo implantation and affects embryo spacing in the womb (Ye et al., 2005; Hama et al., 2007).
Positive_regulation (up-regulated) of LPA3 receptor in embryo
5) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.25 Pain Relevance 0.03
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Positive_regulation (evidence) of LPA3
6) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.29

General Comments

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