INT287743

Context Info Confidence 0.44 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.48 Pain Relevance 0.39

signal transduction (Lpar2, Lpar1) signal transducer activity (Lpar2, Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)

Anatomy Link Frequency epithelial cells 2 Lpar2 (Mus musculus) Lpar1 (Mus musculus)

Pain Link Frequency Relevance Heat allodynia 5 96.20 Thermal hyperalgesia 2 95.20 Spinal cord 39 90.88 Central nervous system 1 47.84 Neuropathic pain 12 10.88 Sciatic nerve 8 5.00 Pain 7 5.00 spinal dorsal horn 5 5.00 intrathecal 5 5.00 Demyelination 4 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 4 99.24 Neuropathic Pain 17 96.20 Hyperalgesia 5 95.20 Nociception 3 93.12 Nervous System Injury 2 50.00 Ganglion Cysts 9 5.00 Pain 7 5.00 Demyelinating Disease 5 5.00 Urological Neuroanatomy 5 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].

LPA2 Spec (might) Positive_regulation (contribute) of Positive_regulation (induced) of LPA-induced in epithelial cells associated with ovarian cancer

1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.48 Pain Relevance 0.39

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