INT287746

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.72
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Anxa1, Lpar1) signal transduction (Anxa1, Lpar1) plasma membrane (Anxa1, Lpar1)
protein binding, bridging (Anxa1) cilium (Anxa1) protein complex (Anxa1)
Anatomy Link Frequency
dorsal roots 3
dorsal horn 1
Anxa1 (Mus musculus)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 64 99.92 Very High Very High Very High
Spinal cord 312 99.68 Very High Very High Very High
spinal dorsal horn 40 99.68 Very High Very High Very High
dorsal root ganglion 8 98.68 Very High Very High Very High
intrathecal 40 93.08 High High
Neuropathic pain 96 91.60 High High
Central nervous system 8 86.28 High High
Pain 56 84.40 Quite High
qutenza 8 83.04 Quite High
Dorsal horn 32 68.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 72 98.68 Very High Very High Very High
Urological Neuroanatomy 40 91.92 High High
Neuropathic Pain 136 91.60 High High
Pain 56 84.40 Quite High
Ovarian Cancer 32 81.44 Quite High
Nervous System Injury 16 75.00 Quite High
Demyelinating Disease 40 60.32 Quite High
Nociception 24 53.44 Quite High
Hyperalgesia 40 50.00 Quite Low
Disease 8 34.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the increase observed in atx+/- mice was severely limited, suggesting that LPC-induced LPA production largely depends on the ATX action in vivo.
LPC Positive_regulation (induced) of Gene_expression (production) of LPA
1) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.19 Pain Relevance 0.21
It should be noted that LPA production induced by LPC markedly increased with time, until 3 h had passed.
LPC Positive_regulation (induced) of Gene_expression (production) of LPA
2) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.15 Pain Relevance 0.21
The present study was an initial neurochemical examination of the processes underlying LPC-induced LPA production, and provides evidence of feed-forward LPA production through the LPA3 receptor.


LPC Positive_regulation (induced) of Gene_expression (production) of LPA
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.61 Pain Relevance 0.71
LPC-induced LPA production in the SC and DR was attenuated in atx+/- mice at 1 h after LPC treatment, compared with WT mice (Fig. 2a).
LPC Positive_regulation (induced) of Gene_expression (production) of LPA associated with spinal cord
4) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.31
LPC induces LPA production in the spinal dorsal horn and dorsal roots
LPC Positive_regulation (induces) of Gene_expression (production) of LPA in dorsal roots associated with spinal dorsal horn
5) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.08
ATX and LPA3 receptors are required in LPC-induced LPA production
LPC Positive_regulation (induced) of Gene_expression (production) of LPA
6) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.30
LPC-induced LPA production was markedly diminished in ATX heterozygotes, and was abolished in mice that were deficient in LPA3, but not LPA1 or LPA2 receptors.
LPC Positive_regulation (induced) of Gene_expression (production) of LPA
7) Confidence 0.04 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2780384 Disease Relevance 0.40 Pain Relevance 0.57
LPC induces LPA production in the spinal dorsal horn and dorsal roots
LPC Positive_regulation (induces) of in dorsal horn Gene_expression (production) of LPA in dorsal roots associated with spinal dorsal horn
8) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.08

General Comments

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