INT287749

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) nucleus (Dmbx1)
DNA binding (Dmbx1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Anatomy Link Frequency
spinal cord 4
Dmbx1 (Mus musculus)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 78 99.58 Very High Very High Very High
intrathecal 10 98.08 Very High Very High Very High
Neuropathic pain 24 93.60 High High
Sciatic nerve 16 86.20 High High
dorsal root ganglion 2 84.96 Quite High
Hyperalgesia 6 83.60 Quite High
spinal dorsal horn 10 82.80 Quite High
allodynia 10 82.24 Quite High
Thermal hyperalgesia 4 77.20 Quite High
Pain 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 34 93.60 High High
Ganglion Cysts 18 84.96 Quite High
Hyperalgesia 10 83.60 Quite High
Nervous System Injury 4 75.00 Quite High
Pain 14 5.00 Very Low Very Low Very Low
Demyelinating Disease 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Ovarian Cancer 8 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor.
ATX Positive_regulation (mediated) of Gene_expression (production) of LPA in spinal cord associated with spinal cord
1) Confidence 0.41 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2780384 Disease Relevance 0.39 Pain Relevance 0.57
As the ATX-dependent LPA production was detected in the supernatant of spinal cord slices in the present in vitro assay, it appears that this synthesis occurs in the extracellular space.


ATX Positive_regulation (dependent) of Gene_expression (production) of LPA in spinal cord associated with spinal cord
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.44 Pain Relevance 0.58

General Comments

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