INT287775

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.27
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
hypothalamus 1
neurons 1
gland 1
Ghrl (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 9 99.34 Very High Very High Very High
Inflammation 8 91.86 High High
antagonist 41 91.40 High High
agonist 10 79.68 Quite High
Somatostatin 19 60.40 Quite High
gABA 6 57.28 Quite High
Opioid 2 40.60 Quite Low
tolerance 36 5.00 Very Low Very Low Very Low
Action potential 24 5.00 Very Low Very Low Very Low
nud 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peptic Ulcer 10 92.74 High High
Frailty 8 92.36 High High
INFLAMMATION 9 91.86 High High
Sprains And Strains 10 91.14 High High
Infection 33 88.12 High High
Stomach Cancer 37 87.10 High High
Metaplasia 13 86.72 High High
Apoptosis 10 74.80 Quite High
Gastritis 18 66.12 Quite High
Death 1 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, whereas ghrelin-positive synapses connect NPY neurons and GABAergic synapses [12], it is unknown if ghrelin neurons synapse onto GHRH neurons.
Transcription (synapse) of ghrelin in neurons associated with gabaergic
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.22
GHSR1b mRNA is as widely expressed as ghrelin, whereas GHSR1a gene expression is concentrated in the hypothalamus-pituitary unit, although it is also distributed in other central and peripheral tissues [15].
Transcription (expressed) of ghrelin in hypothalamus
2) Confidence 0.34 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
On the contrary, in another study, it was observed that ghrelin (1?
Transcription (observed) of ghrelin
3) Confidence 0.29 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0.05
In addition, intestinal metaplasia and gastric cancer developed in some gerbils with wild-type infection but not in animals infected with the cagE-negative mutant.54 These findings were confirmed by showing that the repaired cagE-positive H. pylori strain induced severe gastric inflammation, gastric mucosal atrophy, and gastric ulcer formation.55 Recently, the nucleotide sequences of cDNAs encoding preproghrelin, a precursor of ghrelin (an appetite-promoting endocrine peptide produced mainly from A-like cells in the gastric fundus)52,56 and sonic hedgehog, a morphogen that may regulate and organize fundic gland epithelial differentiation, have been identified in the Mongolian gerbil.53,57 Preproghrelin and sonic hedgehog mRNA expression is significantly reduced in the gastric mucosa of Mongolian gerbils with persistent H. pylori colonization.52,53
Transcription (expression) of Preproghrelin in gland associated with inflammation, frailty, metaplasia, peptic ulcer, sprains and strains, infection and stomach cancer
4) Confidence 0.02 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780612 Disease Relevance 1.27 Pain Relevance 0.05

General Comments

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