INT287799

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 7.39
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (AIP) cytoplasm (AIP) signal transducer activity (AIP)
cytosol (AIP) signal transduction (AIP) nucleolus (AIP)
Anatomy Link Frequency
pancreas 4
bile duct 2
AIP (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 164 100.00 Very High Very High Very High
Bile 72 100.00 Very High Very High Very High
abdominal pain 4 87.84 High High
Inflammation 84 77.52 Quite High
imagery 24 74.32 Quite High
Pain 8 73.92 Quite High
Chronic pancreatitis 40 73.04 Quite High
positron emission tomography 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 676 100.00 Very High Very High Very High
Disease 160 100.00 Very High Very High Very High
Retroperitoneal Fibrosis 60 100.00 Very High Very High Very High
Obstructive Jaundice 32 100.00 Very High Very High Very High
Pathologic Constriction 32 100.00 Very High Very High Very High
Sclerosing Cholangitis 68 99.80 Very High Very High Very High
Exocrine Pancreatic Insufficiency 8 98.88 Very High Very High Very High
Recurrence 8 98.68 Very High Very High Very High
Cv General 2 Under Development 44 94.72 High High
Fibrosis 116 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our 1- to 22-year follow-up study of AIP patients, the prognosis was almost always good, except in two patients who progressed to pancreatic insufficiency after resection.82 It has been reported that recurrent attacks of AIP result in pancreatic stone formation in some cases.38

Clinical subtype

Positive_regulation (result) of Gene_expression (attacks) of AIP associated with exocrine pancreatic insufficiency and pancreatitis
1) Confidence 0.42 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.71 Pain Relevance 0.23
Localized AIP may extend progressively to the whole pancreas.18,19 The current concept of AIP, including associated extrapancreatic lesions, suggests that AIP may be a systemic disease.7,8,20,21
Positive_regulation (pancreas.18,19) of Gene_expression (extend) of AIP in pancreas associated with pancreatitis and disease
2) Confidence 0.42 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.95 Pain Relevance 0.38
Localized AIP may extend progressively to the whole pancreas.18,19 The current concept of AIP, including associated extrapancreatic lesions, suggests that AIP may be a systemic disease.7,8,20,21
Positive_regulation (pancreas.18,19) of Gene_expression (extend) of AIP in pancreas associated with pancreatitis and disease
3) Confidence 0.42 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.97 Pain Relevance 0.38
The indications for steroid therapy in AIP include obstructive jaundice due to stenosis of the bile duct or the presence of other associated systemic diseases, such as retroperitoneal fibrosis.79 Steroid therapy is also effective for sclerosing cholangitis that relapses after surgery.80,81
Positive_regulation (effective) of Gene_expression (therapy) of AIP in bile duct associated with bile, pancreatitis, sclerosing cholangitis, disease, recurrence, obstructive jaundice, fibrosis, pathologic constriction and retroperitoneal fibrosis
4) Confidence 0.42 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.75 Pain Relevance 0.20

General Comments

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