INT287819

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80, Cd28) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
T-cell 1
CD80 (Homo sapiens)
Cd28 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 34 95.88 Very High Very High Very High
cytokine 24 88.32 High High
Leflunomide 1 76.92 Quite High
Inflammation 18 63.20 Quite High
Arthritis 27 50.84 Quite High
chemokine 5 44.16 Quite Low
imagery 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 95.88 Very High Very High Very High
Autoimmune Disease 17 65.60 Quite High
INFLAMMATION 22 63.20 Quite High
Arthritis 29 50.84 Quite High
Disease 9 19.00 Low Low
Bacterial Infection 1 12.04 Low Low
Multiple Sclerosis 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A fusion protein comprised of CTLA4 fused to an immunoglobulin Fc portion (CTLA-4Ig), which binds to the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) and thus prevents CD28/B7 interaction and subsequent activation of the CD28 receptor on T cells, appears to be highly effective in treating RA.13 Although these data will have to be confirmed in further trials, not only do these results suggest that therapies directed at interfering with T-cell activities may be as effective as other DMARDs, but also that T cells are involved in the pathogenesis of RA.
CD80 Binding (interaction) of CD28 in T-cell associated with rheumatoid arthritis
1) Confidence 0.25 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.70 Pain Relevance 0.40

General Comments

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