INT287841

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 32 99.50 Very High Very High Very High
long-term potentiation 19 99.34 Very High Very High Very High
dexamethasone 128 99.20 Very High Very High Very High
agonist 4 90.32 High High
Glutamate receptor 2 90.00 High High
adenocard 1 19.52 Low Low
addiction 3 11.60 Low Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
Pyramidal cell 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 32 99.50 Very High Very High Very High
Cognitive Disorder 25 84.40 Quite High
Pulmonary Disease 3 55.08 Quite High
Targeted Disruption 4 46.08 Quite Low
Body Weight 8 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Coronary Heart Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the finding that the phosphorylation level of MLC-2 was not increased may be attributed by substrate specificity of the (Ca2+-dependent) kinases and phosphatases involved.


Neg (not) Positive_regulation (increased) of Phosphorylation (phosphorylation) of Ca2
1) Confidence 0.18 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
The effects of DEX on LTP and LTD were correlated with an increase in the autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at threonine-286 and a decrease in the protein phosphatase 1 expression.
Positive_regulation (increase) of Phosphorylation (autophosphorylation) of Ca2 associated with depression, long-term potentiation and dexamethasone
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943478 Disease Relevance 0.58 Pain Relevance 0.75

General Comments

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