INT287850

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnni3)
Anatomy Link Frequency
heart 4
filament 2
Tnni3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thoracotomy 6 60.08 Quite High
ketamine 6 54.48 Quite High
adenocard 6 52.32 Quite High
agonist 6 14.60 Low Low
lidocaine 30 5.00 Very Low Very Low Very Low
addiction 18 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 88.04 High High
Hypertrophic Cardiomyopathy 6 22.16 Low Low
Coronary Heart Disease 6 5.00 Very Low Very Low Very Low
Myocardial Infarction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiac MyBP-C and cTnI phosphorylation were markedly increased (3.7-fold) in the Isoprenaline group relative to the Quiescence group (P<0.01).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of cTnI
1) Confidence 0.54 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
D, E Effect of incubation of tissue from the Quiescence group with the active subunit of protein kinase A. cMyBP-C and cTnI phosphorylation increased with the duration of the incubation and saturated after approximately 30 min.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of cTnI
2) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
This latter finding suggests that Isoprenaline also caused phosphorylation of other sites on cMyBP-C and cTnI, distinct from the PKA-sites (cTnI: Ser23/24; cMyBP-C: S279/288/308).


Positive_regulation (caused) of Phosphorylation (phosphorylation) of cTnI
3) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
In human tissue, our laboratory has presented evidence that the effects of MLC-2 dephosphorylation depend on the level of cTnI phosphorylation, i. e. an interaction between the effect of the phosphorylation of a thin (actin) filament protein and that of a thick (myosin) filament protein [42].
Positive_regulation (depend) of Phosphorylation (phosphorylation) of cTnI in filament
4) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.09 Pain Relevance 0.06
Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.
Positive_regulation (elevations) of Phosphorylation (phosphorylation) of cTnI in heart
5) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.
Neg (not) Positive_regulation (caused) of Phosphorylation (phosphorylation) of cTnI in heart
6) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03

General Comments

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