INT287850

Context Info Confidence 0.54 First Reported 2007 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0.09 Pain Relevance 0.11

cytoplasm (Tnni3)

Anatomy Link Frequency heart 4 filament 2 Tnni3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Thoracotomy 6 60.08 ketamine 6 54.48 adenocard 6 52.32 agonist 6 14.60 lidocaine 30 5.00 addiction 18 5.00 imagery 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 18 88.04 Hypertrophic Cardiomyopathy 6 22.16 Coronary Heart Disease 6 5.00 Myocardial Infarction 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cardiac MyBP-C and cTnI phosphorylation were markedly increased (3.7-fold) in the Isoprenaline group relative to the Quiescence group (P<0.01).

Positive_regulation (increased) of Phosphorylation (phosphorylation) of cTnI

1) Confidence 0.54 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0

D, E Effect of incubation of tissue from the Quiescence group with the active subunit of protein kinase A. cMyBP-C and cTnI phosphorylation increased with the duration of the incubation and saturated after approximately 30 min.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of cTnI

2) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0

This latter finding suggests that Isoprenaline also caused phosphorylation of other sites on cMyBP-C and cTnI, distinct from the PKA-sites (cTnI: Ser23/24; cMyBP-C: S279/288/308).

Positive_regulation (caused) of Phosphorylation (phosphorylation) of cTnI

3) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0

In human tissue, our laboratory has presented evidence that the effects of MLC-2 dephosphorylation depend on the level of cTnI phosphorylation, i. e. an interaction between the effect of the phosphorylation of a thin (actin) filament protein and that of a thick (myosin) filament protein [42].

Positive_regulation (depend) of Phosphorylation (phosphorylation) of cTnI in filament

4) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.09 Pain Relevance 0.06

Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.

Positive_regulation (elevations) of Phosphorylation (phosphorylation) of cTnI in heart

5) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03

Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.

Neg (not) Positive_regulation (caused) of Phosphorylation (phosphorylation) of cTnI in heart

6) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03

General Comments

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