INT287858

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Mlc1) endosome (Mlc1) vesicle-mediated transport (Mlc1)
endoplasmic reticulum (Mlc1) plasma membrane (Mlc1) lysosome (Mlc1)
Anatomy Link Frequency
hearts 1
Mlc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 7 86.80 High High
agonist 7 81.08 Quite High
imagery 7 53.92 Quite High
addiction 21 6.24 Low Low
lidocaine 35 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
Thoracotomy 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Coronary Heart Disease 7 5.00 Very Low Very Low Very Low
Hypertrophic Cardiomyopathy 7 5.00 Very Low Very Low Very Low
Myocardial Infarction 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant differences were found in the phosphorylation of cMyBP-C, cTnI, MLC-1 and MLC-2 in the three groups (ANOVA),while cTnT phosphorylation (approximately 80% of total cTnT) remained the same.
Phosphorylation (phosphorylation) of MLC-1
1) Confidence 0.20 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
MLC-1 was mainly in the dephosphorylated form; the MLC-1 phosphorylation was increased slightly (P<0.05) from 13.5 % in the Quiescence group to 19% in the Isoprenaline group (Table 2).
Phosphorylation (phosphorylation) of MLC-1
2) Confidence 0.20 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
The kinase involved in MLC-1 phosphorylation is unknown: it could be phosphorylated in vitro by MLCK, but only in the presence of ATP?
Phosphorylation (phosphorylation) of MLC-1
3) Confidence 0.20 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.08
The 2D-gels (pH range 4–7) allow the distinction between different phosphorylated forms of cTnT,MLC-1 and MLC-2 and permit the quantification of the relative distribution of these forms of each protein.
Phosphorylation (phosphorylated) of MLC-1
4) Confidence 0.20 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
MLC-1 phosphorylation increased significantly from 13.5±0.6% to 19.0±1.7 % in the Isoprenaline group.
Phosphorylation (phosphorylation) of MLC-1
5) Confidence 0.17 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.08
Freeze dried samples were homogenized in 1D sample buffer (62.5 mM TRIS (pH 6.8), 15% glycerol, 1% SDS and 1.5% hydroxyethyldisulfide), and diluted [1:17] in 2D sample buffer (7 M urea, 2.5 M thiourea, 4% CHAPS, 0.5% ampholytes pH 4–7, 10% glycerol and 10 % isopropanol). 2D-gel electrophoresis of the samples (200 µg dry weight) was performed using immobiline strips with a pH gradient of 4–7 as described previously [42] to determine MLC-1, MLC-2 and cTnT phosphorylation from the Coomassie stained gels.


Phosphorylation (phosphorylation) of MLC-1
6) Confidence 0.15 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
In quiescent Langendorff-perfused hearts MLC-1, MLC-2, cMyBP-C and cTnI were mainly dephosphorylated, indicating that the relevant balance had been shifted in favour of phosphatase activity.
Phosphorylation (dephosphorylated) of MLC-1 in hearts
7) Confidence 0.13 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.07

General Comments

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