INT287878

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1, CREBBP) signal transduction (CREB1, CREBBP) nucleus (CREB1, CREBBP)
transcription factor binding (CREB1, CREBBP) mitochondrion (CREB1) small molecule metabolic process (CREBBP)
CREB1 (Homo sapiens)
CREBBP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 84.60 Quite High
cytokine 1 68.88 Quite High
cINOD 13 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
diclofenac 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 4 81.12 Quite High
Apoptosis 18 43.04 Quite Low
Colon Cancer 10 41.52 Quite Low
Cancer 81 18.72 Low Low
Disease 33 5.00 Very Low Very Low Very Low
Urinary Tract Infection 32 5.00 Very Low Very Low Very Low
Pyelonephritis 30 5.00 Very Low Very Low Very Low
Infection 27 5.00 Very Low Very Low Very Low
Colorectal Cancer 18 5.00 Very Low Very Low Very Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB is then phosphorylated and binds to CBP (CREB-binding protein), which preferentially associates with phosphorylated IRF3 [38], [39], leading to IRF3.
CREB Binding (binds) of CBP
1) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.16 Pain Relevance 0.03
CBP or its closely related homolog p300 were initially identified in protein interaction assays, first through their association with the transcription factor CREB [172] and later through their interaction with the adenoviral-transforming protein E1A [173].
transcription factor CREB Binding (association) of CBP
2) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.08

General Comments

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