INT287883

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
plasma membrane (EPHB2) nucleus (FOS)
FOS (Homo sapiens)
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 6 98.72 Very High Very High Very High
Inflammation 2 74.04 Quite High
cINOD 13 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 81 91.00 High High
Metastasis 4 90.04 High High
Disease 18 78.04 Quite High
INFLAMMATION 2 74.04 Quite High
Affective Disorder 1 73.48 Quite High
Diabetes Mellitus 2 72.00 Quite High
Leukemia 2 31.76 Quite Low
Colon Cancer 10 5.68 Low Low
Adenoma 2 5.52 Low Low
Colorectal Cancer 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several mechanisms of action might be relevant for the biological activity of VPA: (1) VPA increases the DNA binding ability of activating protein-1 (AP-1) transcription factor, and the expression of genes regulated by the extracellular-regulated kinase (ERK)-AP-1 pathway; (2) VPA downregulates protein kinase C (PKC) activity; (3) VPA inhibits GSK3?
AP-1 Regulation (regulated) of Gene_expression (expression) of ERK associated with kinase c
1) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.87 Pain Relevance 0.14

General Comments

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