INT287913

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.12
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
SFRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
cINOD 13 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
diclofenac 1 5.00 Very Low Very Low Very Low
cOX1 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Radiation Pneumonitis 72 100.00 Very High Very High Very High
Cancer 85 97.18 Very High Very High Very High
Pulmonary Disease 8 84.12 Quite High
Colon Cancer 10 81.68 Quite High
Apoptosis 18 81.28 Quite High
Non-small-cell Lung Cancer 9 71.76 Quite High
Cardiovascular Disease 1 63.92 Quite High
Lung Cancer 16 50.00 Quite Low
Diabetes Mellitus 4 36.04 Quite Low
Nicotine Addiction 3 35.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cancer cell growth may be inhibited by an agent that would selectively inhibit the binding of the Wnt protein with its Fzd receptor or which would upregulate the expression of endogenous antagonists such as sFRP,WIF-1, Cerberus or DKK.
Positive_regulation (upregulate) of Gene_expression (expression) of sFRP,WIF-1 associated with cancer and antagonist
1) Confidence 0.25 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.88 Pain Relevance 0.05
Table 4 shows the association between the dosimetric Parameters (NTCP/V10) and the incidence of SARP for 94 patients; the incidences of SARP in the group with NTCP > 4.2% and NTCP ?
Positive_regulation (with) of Gene_expression (incidence) of SARP associated with radiation pneumonitis
2) Confidence 0.17 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2883984 Disease Relevance 1.24 Pain Relevance 0

General Comments

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