INT287920

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DVL1) cytoplasm (DVL1) signal transducer activity (DVL1)
cytosol (DVL1) signal transduction (DVL1) plasma membrane (DVL1)
DVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 54.96 Quite High
monoamine 1 13.12 Low Low
cINOD 18 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 43 90.80 High High
Adhesions 6 89.84 High High
Targeted Disruption 4 84.36 Quite High
Familial Adenomatous Polyposis 19 73.28 Quite High
Cancer 138 65.12 Quite High
Helminth Infection 2 63.44 Quite High
Disease 23 63.28 Quite High
Depression 1 54.96 Quite High
Hematologic Neoplasms 22 54.80 Quite High
Carcinoma 26 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activation requires Dvl-Rho complex formation which is assisted by Daam1.
Positive_regulation (requires) of Dvl
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929951 Disease Relevance 0.50 Pain Relevance 0.03
Activation of Dvl induces the dissociation of GSK-3?
Positive_regulation (Activation) of Dvl
2) Confidence 0.12 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.31 Pain Relevance 0
Upon ligation to their receptors, the cytoplasmic protein disheveled (Dvl) is recruited, phosphorylated and activated.
Positive_regulation (activated) of Dvl
3) Confidence 0.12 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.26 Pain Relevance 0
One hypothetical pathway leads to Dvl activation.
Positive_regulation (activation) of Dvl
4) Confidence 0.10 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.

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