INT287922

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DVL1) cytoplasm (DVL1) signal transducer activity (DVL1)
cytosol (DVL1) signal transduction (DVL1) plasma membrane (DVL1)
DVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 12 96.40 Very High Very High Very High
antagonist 22 15.56 Low Low
cINOD 30 5.00 Very Low Very Low Very Low
aspirin 14 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 78 78.60 Quite High
Malignant Neoplastic Disease 9 77.40 Quite High
Apoptosis 64 74.40 Quite High
Familial Adenomatous Polyposis 20 73.28 Quite High
Adhesions 6 65.28 Quite High
Helminth Infection 1 63.44 Quite High
Disease 41 60.48 Quite High
Hematologic Neoplasms 12 55.24 Quite High
Toxicity 5 50.00 Quite Low
Carcinoma 16 48.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon ligation to their receptors, the cytoplasmic protein disheveled (Dvl) is recruited, phosphorylated and activated.
Phosphorylation (phosphorylated) of Dvl
1) Confidence 0.20 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.26 Pain Relevance 0
After Wnt binding, Dvl is phosphorylated and through its association with Axin, prevents glycogen synthase kinase 3?
Phosphorylation (phosphorylated) of Dvl
2) Confidence 0.17 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
-catenin pathway by phosphorylating Dvl [33].
Phosphorylation (phosphorylating) of Dvl
3) Confidence 0.15 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.07 Pain Relevance 0.12
Subsequently the cytoplasmic adaptor protein disheveled (Dvl) is phosphorylated and inhibits glycogen synthase kinase (GSK)-3?
Phosphorylation (phosphorylated) of Dvl
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.88 Pain Relevance 0

General Comments

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