INT287927

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.23
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (THEMIS) cytoplasm (THEMIS)
THEMIS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 73.68 Quite High
antagonist 35 63.72 Quite High
Kinase C 30 12.00 Low Low
cINOD 65 5.00 Very Low Very Low Very Low
aspirin 35 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
vincristine 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 405 99.84 Very High Very High Very High
Manic Depressive Disorder 15 99.30 Very High Very High Very High
Intestinal Cancer 10 99.24 Very High Very High Very High
Disease 90 98.98 Very High Very High Very High
Neurological Disease 5 82.12 Quite High
Diabetes Mellitus 10 77.44 Quite High
Apoptosis 90 75.36 Quite High
Affective Disorder 5 74.96 Quite High
INFLAMMATION 10 73.68 Quite High
Metastasis 20 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gould et al. recently investigated the effects of lithium in a murine model predisposed to the formation of tumors due to activation of the Wnt pathway (the APC multiple intestinal neoplasia (min) mouse) [159].
Positive_regulation (activation) of pathway associated with cancer and intestinal cancer
1) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.16 Pain Relevance 0
Depending on the pathway which is activated, the initiation signal will be transduced differently.
Positive_regulation (activated) of pathway
2) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.06 Pain Relevance 0
inhibitor is used for treatment of bipolar disorder as well as in cancer research, to activate the Wnt signaling pathway as a model for carcinogenesis.
Positive_regulation (activate) of pathway associated with manic depressive disorder and cancer
3) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.17 Pain Relevance 0
Signal transduction systems known to be perturbed by lithium involve phosphoinositide (PI) turnover, activation of the Wnt pathway via inhibition of GSK3?
Positive_regulation (activation) of pathway
4) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.52 Pain Relevance 0.04
Given that the Wnt signaling pathway is implicated in a substantial number of diseases, and given that a number of mutations lead to the activation of this pathway and cancer in several tissues, there is a clear need for drugs that attenuate the nuclear functions of ?
Positive_regulation (activation) of pathway associated with cancer and disease
5) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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